This is a request for continuation of our institutional NRSA which has been funded since 1986. The application requests support for 15 postdoctoral trainees and 6 predoctoral trainees. The postdoctoral program will train both M.D.'s and Ph.D.'s who are interested in lung disease and who will pursue independent research careers in universities, research institutes or schools of medicine. The primary activity of the postdoctoral trainees will be research related to lung disease conducted under the guidance of an appropriate mentor. Postdoctoral trainees will also participate in a variety of educational activities, designed to enable- them to profit from the collective expertise of an unusually varied pulmonary community. These will include participation in basic science courses, internal laboratory discussions, weekly research meeting of the pulmonary group and highlight sessions after national meetings. They will also be expected to write (with the guidance of their mentor) a grant and submit it to the NIH, AHA or VA for funding. The predoctoral program will focus on individuals interested in lung disease who will receive a Ph.D. in Microbiology, Biochemistry, Anatomy and Cell Biology, Epidemiology, Molecular Biology, Immunology, Physiology and Biophysics. The training will be provided in an interdisciplinary manner and will focus on studies related to molecular and cellular biology of the lung. The training faculty all have laboratories in the Eckstein Medical Research Building, Bowen Science Building, Steindler Building, or the medical laboratories, all of which are interconnected and physically next to each other. Candidates will be chosen by an Executive Committee, chaired by Dr. Hunninghake, and the major criteria for selection will be the probability (as judged by the committee) that the individual candidate will develop into a first-class independent researcher, capable of achieving a faculty appointment at a major university, medical school, or research institute. At the levels requested, the training grant will support only about 1/3 of the individuals to be trained and more than enough excellent candidates are available to the program to make the training grant positions highly competitive. Internal and external reviews of the program on a yearly basis and provide advice to the director of the program.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007638-19
Application #
6768668
Study Section
Special Emphasis Panel (ZHL1-CSR-M (F1))
Program Officer
Colombini-Hatch, Sandra
Project Start
1986-07-01
Project End
2006-06-30
Budget Start
2004-07-01
Budget End
2005-06-30
Support Year
19
Fiscal Year
2004
Total Cost
$859,625
Indirect Cost
Name
University of Iowa
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Danielson, Samantha J; Rappaport, Charles A; Loher, Michael K et al. (2018) Looking for light in the din: An examination of the circadian-disrupting properties of a medical intensive care unit. Intensive Crit Care Nurs 46:57-63
Morselli, Lisa L; Claflin, Kristin E; Cui, Huxing et al. (2018) Control of Energy Expenditure by AgRP Neurons of the Arcuate Nucleus: Neurocircuitry, Signaling Pathways, and Angiotensin. Curr Hypertens Rep 20:25
Child, Daniel D; Lee, John H; Pascua, Christine J et al. (2018) Cardiac mTORC1 Dysregulation Impacts Stress Adaptation and Survival in Huntington's Disease. Cell Rep 23:1020-1033
Hisert, Katherine B; Heltshe, Sonya L; Pope, Christopher et al. (2017) Restoring Cystic Fibrosis Transmembrane Conductance Regulator Function Reduces Airway Bacteria and Inflammation in People with Cystic Fibrosis and Chronic Lung Infections. Am J Respir Crit Care Med 195:1617-1628
Deonovic, Benjamin; Wang, Yunhao; Weirather, Jason et al. (2017) IDP-ASE: haplotyping and quantifying allele-specific expression at the gene and gene isoform level by hybrid sequencing. Nucleic Acids Res 45:e32
Li, Xiaopeng; Vargas Buonfiglio, Luis G; Adam, Ryan J et al. (2017) Cystic Fibrosis Transmembrane Conductance Regulator Potentiation as a Therapeutic Strategy for Pulmonary Edema: A Proof-of-Concept Study in Pigs. Crit Care Med 45:e1240-e1246
Rauckhorst, Adam J; Gray, Lawrence R; Sheldon, Ryan D et al. (2017) The mitochondrial pyruvate carrier mediates high fat diet-induced increases in hepatic TCA cycle capacity. Mol Metab 6:1468-1479
Cook, Daniel P; Adam, Ryan J; Zarei, Keyan et al. (2017) CF airway smooth muscle transcriptome reveals a role for PYK2. JCI Insight 2:
Adam, Ryan J; Hisert, Katherine B; Dodd, Jonathan D et al. (2016) Acute administration of ivacaftor to people with cystic fibrosis and aG551D-CFTRmutation reveals smooth muscle abnormalities. JCI Insight 1:e86183
Rauckhorst, Adam J; Taylor, Eric B (2016) Mitochondrial pyruvate carrier function and cancer metabolism. Curr Opin Genet Dev 38:102-109

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