Ion channels and transporter proteins are ubiquitous molecules that serve a variety of important physiological functions, provide targets for many types of pharmacological agents, and are encoded by genes that can be the basis for inherited diseases affecting the nervous system and other tissues. This proposal describes a new Training Program in Ion Channel and Transporter Biology that will strive to provide multidisciplinary research training for pre-doctoral and post-doctoral basic scientists and physicianscientists. This highly focused training program will involve 18 NIH-funded mentors in 7 different academic departments at Vanderbilt University with strong records of accomplishments in the ion channel and transporter field, and with a deep commitment to training students and postdoctoral fellows. Based on the breadth of research expertise of the training faculty, trainees can be expected to gain experiences in one or more of the following disciplines: physiology, pharmacology, neuroscience, molecular biology, structural biology, and genetics. Pre-doctoral students will be recruited from a national pool of applicants who apply for graduate studies in our Interdisciplinary Graduate and Medical Scientist Training Programs. Additional pre-doctoral students may emerge from our Medical Scholars Program, an innovative research leave program in the Vanderbilt Medical School. Post-doctoral trainees will be selected from the pool of applicants that apply to preceptor laboratories as well as physicianscientist applicants from various clinical training programs at the Vanderbilt University Medical Center. In addition to intensive research experiences, both pre-doctoral and post-doctoral trainees will have rigorous didactic course requirements, and have formal mentoring and career guidance. The goal of the training program is to develop basic scientists and physicianscientists with strong commitments to academic biomedical research in ion channel and transporter biology especially in areas with direct relevance to human health and disease.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Institutional National Research Service Award (T32)
Project #
5T32NS007491-03
Application #
6605817
Study Section
NST-2 Subcommittee (NST)
Program Officer
Stewart, Randall
Project Start
2001-07-20
Project End
2006-06-30
Budget Start
2003-07-01
Budget End
2004-06-30
Support Year
3
Fiscal Year
2003
Total Cost
$194,444
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Robson, Matthew J; Quinlan, Meagan A; Margolis, Kara Gross et al. (2018) p38? MAPK signaling drives pharmacologically reversible brain and gastrointestinal phenotypes in the SERT Ala56 mouse. Proc Natl Acad Sci U S A 115:E10245-E10254
Karasik, Agnes; Ledwitch, Kaitlyn Victoria; Arányi, Tamás et al. (2018) Boosted coupling of ATP hydrolysis to substrate transport upon cooperative estradiol-17-?-D-glucuronide binding in a Drosophila ATP binding cassette type-C transporter. FASEB J 32:669-680
Johnson, Christopher N; Potet, Franck; Thompson, Matthew K et al. (2018) A Mechanism of Calmodulin Modulation of the Human Cardiac Sodium Channel. Structure 26:683-694.e3
Melchior, James R; Jones, Sara R (2017) Chronic ethanol exposure increases inhibition of optically targeted phasic dopamine release in the nucleus accumbens core and medial shell ex vivo. Mol Cell Neurosci 85:93-104
Koehler Leman, Julia; Mueller, Benjamin K; Gray, Jeffrey J (2017) Expanding the toolkit for membrane protein modeling in Rosetta. Bioinformatics 33:754-756
Parikh, Shan S; Blackwell, Daniel J; Gomez-Hurtado, Nieves et al. (2017) Thyroid and Glucocorticoid Hormones Promote Functional T-Tubule Development in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Circ Res 121:1323-1330
Gomez-Hurtado, Nieves; Blackwell, Daniel Jesse; Knollmann, Bjorn Christian (2017) Modelling human calmodulinopathies with induced pluripotent stem cells: progress and challenges. Cardiovasc Res 113:437-439
Bender, Brian J; Cisneros 3rd, Alberto; Duran, Amanda M et al. (2016) Protocols for Molecular Modeling with Rosetta3 and RosettaScripts. Biochemistry 55:4748-63
Shonesy, Brian C; Winder, Danny G; Patel, Sachin et al. (2015) The initiation of synaptic 2-AG mobilization requires both an increased supply of diacylglycerol precursor and increased postsynaptic calcium. Neuropharmacology 91:57-62
Kroncke, Brett M; Vanoye, Carlos G; Meiler, Jens et al. (2015) Personalized biochemistry and biophysics. Biochemistry 54:2551-9

Showing the most recent 10 out of 51 publications