The primary goal of the MARC U*STAR program at UC at Santa Cruz is to recruit and prepare underrepresented (UR) students for entry into PhD programs in the biomedical sciences. This is achieved through increasing the rate at which UR undergraduates become involved in cutting-edge research. We provide training, experience and guidance towards the pursuit of Ph.D. degrees. Over the past five years, we have seen a dramatic demographic change in our student population at UCSC, more than doubling the number of UR STEM students on our campus. Thus, we have more honors students worthy of MARC support and a more diverse undergraduate population at the institution who can benefit from our expertise. We are requesting 5 years of new support at our current level of 14 MARC scholar trainee slots. We developed several new features of our program over the past five years, and we intend to continue with these proven training aspects. In addition, we are proposing four new project areas. These new specific aims are to: 1 - involve UR transfer students in research opportunities. The State of California Master Plan for Higher Education has made the community colleges an important stepping stone to a UC education. We will reach out to STEM transfer students interested in biomedical research and invite two to join MARC. All will be invited to join our Research Affiliates for Diversity (RAD). 2 - Develop an Honors pre-MARC program. We will directly identify honors UR students in the chemistry and biology intro series early in their sophomore year. No honors programs exist in the biomedical sciences on campus. The opportunity to have a faculty mentor will be a meaningful way to engage bright UR students and introduce them to research science. 3 - Institute team mentoring through individual development plans. We will institute Individualized Development Plans (IDPs) for MARC students. We will work with the faculty mentors, and the graduate students and postdocs who supervise the students, to develop a team approach to student mentoring. 4 - Train MARC Fellows to be prepared for new types of challenges when they enter graduate school, so that they are able to persist to a PhD. We are developing an activity called Facilitated Alumni Mentoring to ensure that our MARC students are prepared for the social and professional challenges they will face in graduate school.

Public Health Relevance

Bringing people from different cultures with diverse life experiences to the research endeavor is an important component of maintaining the innovative edge of research science in the US. The primary goal of the project is to prepare undergraduate students from underrepresented groups for entry into doctoral programs leading to research careers in the biomedical sciences. MARC U*STAR trainees perform important research to advance our understanding of the mechanisms of life.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
MARC Undergraduate NRSA Institutional Grants (T34)
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Study Section
Training and Workforce Development Subcommittee - D (TWD)
Program Officer
Koduri, Sailaja
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University of California Santa Cruz
Public Health & Prev Medicine
Schools of Arts and Sciences
Santa Cruz
United States
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Volden, Roger; Palmer, Theron; Byrne, Ashley et al. (2018) Improving nanopore read accuracy with the R2C2 method enables the sequencing of highly multiplexed full-length single-cell cDNA. Proc Natl Acad Sci U S A 115:9726-9731
Byrne, Ashley; Beaudin, Anna E; Olsen, Hugh E et al. (2017) Nanopore long-read RNAseq reveals widespread transcriptional variation among the surface receptors of individual B cells. Nat Commun 8:16027
White, Pamela M; Serbus, Laura R; Debec, Alain et al. (2017) Reliance of Wolbachia on High Rates of Host Proteolysis Revealed by a Genome-Wide RNAi Screen of Drosophila Cells. Genetics 205:1473-1488
Duncan, Miles C; Herrera, Natalia G; Johnson, Kevin S et al. (2017) Bacterial internalization is required to trigger NIK-dependent NF-?B activation in response to the bacterial type three secretion system. PLoS One 12:e0171406
Lam, Hanh; Schwochert, Joshua; Lao, Yongtong et al. (2017) Synthetic Cyclic Peptomers as Type III Secretion System Inhibitors. Antimicrob Agents Chemother 61:
Jimenez, Jorge; Chakraborty, Indranil; Del Cid, Anthony M et al. (2017) Five- and Six-Coordinated Silver(I) Complexes Derived from 2,6-(Pyridyl)iminodiadamantanes: Sustained Release of Bioactive Silver toward Bacterial Eradication. Inorg Chem 56:4784-4787
Pye, Cameron R; Hewitt, William M; Schwochert, Joshua et al. (2017) Nonclassical Size Dependence of Permeation Defines Bounds for Passive Adsorption of Large Drug Molecules. J Med Chem 60:1665-1672
Lorig-Roach, Nicholas; Still, Patrick C; Coppage, David et al. (2017) Evaluating Nitrogen-Containing Biosynthetic Products Produced by Saltwater Culturing of Several California Littoral Zone Gram-Negative Bacteria. J Nat Prod 80:2304-2310
Green, Abigail R; Barbour, Shannon; Horn, Thomas et al. (2016) Strict Regiospecificity of Human Epithelial 15-Lipoxygenase-2 Delineates Its Transcellular Synthesis Potential. Biochemistry 55:2832-40
Desjardins, Christopher A; Cohen, Keira A; Munsamy, Vanisha et al. (2016) Genomic and functional analyses of Mycobacterium tuberculosis strains implicate ald in D-cycloserine resistance. Nat Genet 48:544-51

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