This multifaceted S/T research training program in year 37 at The University of Arizona (UA) introduces, trains and nurtures diverse inquiring medical students in health-related biomedical research; and further, stimulates subsequent intensive and extensive research experiences. Building on the high level of student/faculty participation and esprit-de- corps already generated and the outstanding record of trainee productivity (presentations, publications, awards, and advanced research), 26 (3 month)-39 (2 month) medical students annually will engage in F/T summer/vacation laboratory/clinical investigations with an NHLBI emphasis, fully integrated into an innovative Curriculum on Medical Ignorance. CMI features an intensive Summer Institute (SIMI) and wide variety of year-round enrichment activities open to all students (seminars/ workshops, clinical correlations, Failure/Pondering Rounds, journal clubs, skill practice, Visiting Professors, career advising, and advanced extracurricular research through a popular student-initiated Research Distinction Track). An expanding interactive online Translating Translation presence with an evolving Precision Medicine theme, featured on our unique multimedia Virtual Clinical Research Center/Questionarium web-based mobile accessible platform/grid, focuses on examples, scenarios, and steps in the translation process.
CMI aims to foster attitudes and skills to recognize and deal with the vast shifting world of medical ignorance [what we know we don't know (current research), don't know we don't know (future discovery), and think we know but don't (error)] from molecular to clinical and community medicine. Questioning, critical/creative thinking, communication, team-building, role-modeling, and leadership skills are specifically cultivated to forge a mentoring chain reaction at the local, national, and international level and throughout a diverse NIH-funded multilevel research pipeline continuum. Overseen by an experienced multidisciplinary administrative team and paralleling UA's expanding research strengths, students choose from a spectrum of in vivo, in vitro, in situ, in silico, and modeling approaches to the cardiovascular (CV) system and disorders (cardiac contractility, development, hypertrophy, microcirculation, endothelial biology, electrophysiology, oxygenation, heart failure, resuscitation, CV genomics/proteomics, CV prosthetics, arterial/venous disease, lymphology); pulmonology (asthma, cystic fibrosis, pulmonary hypertension, sleep apnea, organogenesis); and cell-based science/therapy; with cross-cutting themes in bioengineering/multimodal imaging; drug/device discovery R&D; and other topics of specific interest to student researchers and spanning translational steps from bench to bedside to clinical practice and population health. Based on a 37-year track record reflected in followup surveys, we anticipate cultivating an enlarging number of scientific physicians who understand and contribute to the research enterprise and a growing cadre of physician-scientist leaders to replenish the dwindling supply of translational researchers. Detailed S/T and L/T formative/summative program/participant evaluation with database registry, individual development plans, and career portfolios will document efficacy.

Public Health Relevance

Based on a 35-year track record, reflected in our latest Medical Student Research Program followup, we anticipate cultivating a large number of diverse inquiring scientific physicians who understand and can contribute to the research enterprise (emphasizing cardiovascular, lung, and blood disorders, mechanisms, evaluation, and therapy), including a growing cadre of physician-scientist leaders to replenish the dwindling numbers of translational medical researchers. In this way, we will contribute to the concerted effort of NIH and NHLBI to build the diverse enlightened medical research teams of the future, to provide the latest in personalized care and precision medicine, and thereby to expedite the translation of scientific advances from ?bench to bedside to diverse community?.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
NRSA Short -Term Research Training (T35)
Project #
Application #
Study Section
Special Emphasis Panel (ZHL1)
Program Officer
Meadows, Tawanna
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Arizona
Schools of Medicine
United States
Zip Code
Skiba, Meghan B; Luis, Paula B; Alfafara, Chelsea et al. (2018) Curcuminoid Content and Safety-Related Markers of Quality of Turmeric Dietary Supplements Sold in an Urban Retail Marketplace in the United States. Mol Nutr Food Res :e1800143
Flores, Andrew J; Bartlett, Mitchell J; Root, Brandon K et al. (2018) The combination of the opioid glycopeptide MMP-2200 and a NMDA receptor antagonist reduced l-DOPA-induced dyskinesia and MMP-2200 by itself reduced dopamine receptor 2-like agonist-induced dyskinesia. Neuropharmacology 141:260-271
Costello, C M; Ghanavatian, S; Temkit, M et al. (2018) Educational and practice gaps in the management of volar melanocytic lesions. J Eur Acad Dermatol Venereol 32:1450-1455
Moutal, Aubin; Villa, Lex Salas; Yeon, Seul Ki et al. (2018) CRMP2 Phosphorylation Drives Glioblastoma Cell Proliferation. Mol Neurobiol 55:4403-4416
Ye, Tony; Bartlett, Mitchell J; Schmit, Matthew B et al. (2018) Ten-Hour Exposure to Low-Dose Ketamine Enhances Corticostriatal Cross-Frequency Coupling and Hippocampal Broad-Band Gamma Oscillations. Front Neural Circuits 12:61
Anwer, Faiz; Shaukat, Al-Aman; Zahid, Umar et al. (2017) Donor origin CAR T cells: graft versus malignancy effect without GVHD, a systematic review. Immunotherapy 9:123-130
Okolo, Onyemaechi N; Johnson, Ariel C; Yun, Seongseok et al. (2017) Rare transformation to double hit lymphoma in Waldenstrom's macroglobulinemia. Immunotherapy 9:709-714
Harryman, William L; Gard, Jaime M C; Pond, Kelvin W et al. (2017) Targeting the Cohesive Cluster Phenotype in Chordoma via ?1 Integrin Increases Ionizing Radiation Efficacy. Neoplasia 19:919-927
Moutal, Aubin; Eyde, Nathan; Telemi, Edwin et al. (2016) Efficacy of (S)-Lacosamide in preclinical models of cephalic pain. Pain Rep 1:
Frankl, Joseph; Sakata, Michael P; Choudhary, Gagandeep et al. (2016) A Classification System for the Spread of Polymethyl Methacrylate in Vertebral Bodies Treated with Vertebral Augmentation. Tomography 2:197-202

Showing the most recent 10 out of 64 publications