This application is part of the competitive renewal for the """"""""Collaborative Initiative on Fetal Alcohol Spectrum Disorders (CIFASD)"""""""" (Notice RFA-AA-03-004) to continue and expand the current multidisciplinary CIFASD. This RFA calls for, in part, research aimed at """"""""improved diagnosis"""""""" and """"""""enhanced understanding of the domains of neurobehavioral impairment"""""""" of fetal alcohol spectrum disorders (FASD). Although 30 years of research have identified myriad deficits in individuals with FASD, most neuropsychological studies are plagued by the question of global dysfunction vs. a pattern of relative sparing and impaired function. Delineation of a neuropsychological profile has been the subject of much recent debate. Limited research, including the current CIFASD consortium, has examined if prenatal alcohol exposure results in general dysfunction or a more specific neurobehavioral profile of strengths and weaknesses. The primary aim of this project is to determine whether a neurobehavioral phenotype exists in children with fetal alcohol syndrome, whether the same phenotype exists in children with FASD who lack facial dysmorphology, and whether the phenotype can be used for differential diagnosis. Secondary aims, involving collaboration with other CIFASD projects and cores, are to determine the relationship between brain dysmorphology, facial dysmorphology, and neurobehavioral function.
These aims are in keeping with the overall aims of the CIFASD, including enhanced understanding of the neurobehavioral phenotype and establishment of standardized diagnostic criteria and methods of assessment of FASD. A standard neurobehavioral protocol will be administered to four groups of children at six sites and will address the functional domains of executive function, working memory, verbal function, and psychological symptomatology. In addition to children with FASD and nonexposed controls, children with low IQ scores or ADHD will be included as contrast samples. Using this heterogeneous sample and multivariate statistical methods, neurobehavioral profile specific to FASD will be sought. In addition, participants will be assessed using methodology prescribed by the Dysmorphology Core and the facial and brain imaging projects of the CIFASD. Data from three broad domains (neurobehavior, dysmorphology, and brain morphology and function) will be analyzed both separately and together to address the main aim of the CIFASD: improving the diagnostic criteria for FASD. This project is directly relevant to public health concerns surrounding the effects of heavy prenatal alcohol exposure, improving diagnosis of alcohol-affected individuals, and defining the profile of neurobehavioral effects that are specific to FASD. Improved identification and delineation of these features will ultimately lead to improved treatment.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01AA014834-07
Application #
7906069
Study Section
Special Emphasis Panel (ZAA1-CC (11))
Program Officer
Dunty, Jr, William
Project Start
2003-09-30
Project End
2012-07-31
Budget Start
2010-08-01
Budget End
2011-07-31
Support Year
7
Fiscal Year
2010
Total Cost
$688,185
Indirect Cost
Name
San Diego State University
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
073371346
City
San Diego
State
CA
Country
United States
Zip Code
92182
Seewald, P Michelle; De Jesus, Shannon Y; Graves, Lisa V et al. (2018) Age-related differences on a new test of temporal order memory for everyday events. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 25:319-332
Doyle, Lauren R; Moore, Eileen M; Coles, Claire D et al. (2018) Executive Functioning Correlates With Communication Ability in Youth With Histories of Heavy Prenatal Alcohol Exposure. J Int Neuropsychol Soc 24:1026-1037
Gross, Lauren A; Moore, Eileen M; Wozniak, Jeffrey R et al. (2018) Neural correlates of verbal memory in youth with heavy prenatal alcohol exposure. Brain Imaging Behav 12:806-822
Hendrickson, Timothy J; Mueller, Bryon A; Sowell, Elizabeth R et al. (2018) Two-year cortical trajectories are abnormal in children and adolescents with prenatal alcohol exposure. Dev Cogn Neurosci 30:123-133
Glass, Leila; Moore, Eileen M; Akshoomoff, Natacha et al. (2017) Academic Difficulties in Children with Prenatal Alcohol Exposure: Presence, Profile, and Neural Correlates. Alcohol Clin Exp Res 41:1024-1034
Infante, M Alejandra; Moore, Eileen M; Bischoff-Grethe, Amanda et al. (2017) Altered functional connectivity during spatial working memory in children with heavy prenatal alcohol exposure. Alcohol 64:11-21
Wozniak, Jeffrey R; Mueller, Bryon A; Mattson, Sarah N et al. (2017) Functional connectivity abnormalities and associated cognitive deficits in fetal alcohol Spectrum disorders (FASD). Brain Imaging Behav 11:1432-1445
Glass, Leila; Mattson, Sarah N (2017) Fetal Alcohol Spectrum Disorders: A Case Study. J Pediatr Neuropsychol 3:114-135
Hendrickson, Timothy J; Mueller, Bryon A; Sowell, Elizabeth R et al. (2017) Cortical gyrification is abnormal in children with prenatal alcohol exposure. Neuroimage Clin 15:391-400
Panczakiewicz, Amy L; Glass, Leila; Coles, Claire D et al. (2016) Neurobehavioral Deficits Consistent Across Age and Sex in Youth with Prenatal Alcohol Exposure. Alcohol Clin Exp Res 40:1971-81

Showing the most recent 10 out of 52 publications