The broad, overall objective of this Program Project is to study the management of urinary incontinence in noninstitutionalized women. This program will collect psychosocial, functional, medical, pathophysiological, and efficacy data related to the diagnosis and management of urinary incontinence.
The specific aims are: 1)Compare the efficacy of three forms of behavioral therapy: bladder training, pelvic muscle exercises, and bladder training with concomitant pelvic muscle exercises. 2)Assess the efficacy of estrogen supplementation in the management of the syndrome of urinary incontinence. 3)Confirm the mechanism by which surgical intervention affects different outcomes in patients with urinary incontinence and severe genital prolapse. There are three subprojects in this Program: behavioral (subproject 1, estrogen supplementation (subproject 2), and surgical (subproject 3). Subprojects 1 and 2 will be conducted at two sites: Medical College of Virginia/Virginia Commonwealth University and Bowman Gray School of Medicine/Wake Forest University. Subproject 3 will be conducted at Medical College of Virginia only. Information from this project will be instrumental in improving the management of urinary incontinence, and improve selection of diagnostic procedures and interventions with maximal limitation of inconvenience, side effects, costs, and complications.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project--Cooperative Agreements (U01)
Project #
2U01AG005170-06A2
Application #
3546203
Study Section
Aging Review Committee (AGE)
Project Start
1984-09-28
Project End
1995-06-30
Budget Start
1990-07-01
Budget End
1991-06-30
Support Year
6
Fiscal Year
1990
Total Cost
Indirect Cost
Name
Virginia Commonwealth University
Department
Type
Schools of Medicine
DUNS #
City
Richmond
State
VA
Country
United States
Zip Code
23298
Theofrastous, J P; Wyman, J F; Bump, R C et al. (2002) Effects of pelvic floor muscle training on strength and predictors of response in the treatment of urinary incontinence. Neurourol Urodyn 21:486-90
Barber, Matthew D; Visco, Anthony G; Wyman, Jean F et al. (2002) Sexual function in women with urinary incontinence and pelvic organ prolapse. Obstet Gynecol 99:281-9
McClish, D K; Wyman, J F; Sale, P G et al. (1999) Use and costs of incontinence pads in female study volunteers. Continence Program for Women Research Group. J Wound Ostomy Continence Nurs 26:207-8, 210-3
Bump, R C; Hurt, W G; Elser, D M et al. (1999) Understanding lower urinary tract function in women soon after bladder neck surgery. Continence Program for Women Research Group. Neurourol Urodyn 18:629-37
Elser, D M; Wyman, J F; McClish, D K et al. (1999) The effect of bladder training, pelvic floor muscle training, or combination training on urodynamic parameters in women with urinary incontinence. Continence Program for Women Research Group. Neurourol Urodyn 18:427-36
Wyman, J F; Fantl, J A; McClish, D K et al. (1998) Comparative efficacy of behavioral interventions in the management of female urinary incontinence. Continence Program for Women Research Group. Am J Obstet Gynecol 179:999-1007
Bump, R C; Hurt, W G; Addison, W A et al. (1998) Reliability and correlation of measurements during and after bladder neck surgery. The Continence Program for Women Research Group. Br J Urol 82:628-33
Theofrastous, J P; Wyman, J F; Bump, R C et al. (1997) Relationship between urethral and vaginal pressures during pelvic muscle contraction. The Continence Program for Women Research Group. Neurourol Urodyn 16:553-8
Fantl, J A; Bump, R C; Robinson, D et al. (1996) Efficacy of estrogen supplementation in the treatment of urinary incontinence. The Continence Program for Women Research Group. Obstet Gynecol 88:745-9
Bump, R C; Hurt, W G; Theofrastous, J P et al. (1996) Randomized prospective comparison of needle colposuspension versus endopelvic fascia plication for potential stress incontinence prophylaxis in women undergoing vaginal reconstruction for stage III or IV pelvic organ prolapse. The Continence Program for W Am J Obstet Gynecol 175:326-33;discussion 333-5

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