Urinary incontinence represents a major health problem for women living in the community. Approximately 37% of women over the age of 65 suffer lack of urinary control and 17% have associated irritative symptoms. The cost of this condition in this country is estimated to be 8 billion dollars per year. Hypoestrogenism is one correlate of the aging process in women. Evidence suggests that estrogen supplementation has therapeutic benefits in treating older women with urinary incontinence, but its specific efficacy, indication and mode of action is not well understood. This subproject intends to study the effect of estrogen supplementation on hypoestrogenic women who suffer urinary incontinence and live in the community. The primary hypothesis relates to the effect of estrogen supplementation on the number of incontinent episodes. The secondary hypothesis includes its effect on the quantity of fluid loss and diurnal and nocturnal urinary frequency. In addition, it is intended to analyze the therapeutic effect of estrogen supplementation on specific urodynamic variables related to bladder filling and urethral function. The proposed study design is a double-blinded randomized controlled trial. The intervention is represented by a 3-month cycle of estrogen/progesterone treatment with outcome and urodynamic variables assessed before and after intervention. It is expected that the data obtained will serve to improve the management of urinary incontinence in community-dwelling women.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project--Cooperative Agreements (U01)
Project #
2U01AG005170-06A2
Application #
3809242
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
1990
Total Cost
Indirect Cost
Name
Virginia Commonwealth University
Department
Type
DUNS #
City
Richmond
State
VA
Country
United States
Zip Code
23298
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Barber, Matthew D; Visco, Anthony G; Wyman, Jean F et al. (2002) Sexual function in women with urinary incontinence and pelvic organ prolapse. Obstet Gynecol 99:281-9
McClish, D K; Wyman, J F; Sale, P G et al. (1999) Use and costs of incontinence pads in female study volunteers. Continence Program for Women Research Group. J Wound Ostomy Continence Nurs 26:207-8, 210-3
Bump, R C; Hurt, W G; Elser, D M et al. (1999) Understanding lower urinary tract function in women soon after bladder neck surgery. Continence Program for Women Research Group. Neurourol Urodyn 18:629-37
Elser, D M; Wyman, J F; McClish, D K et al. (1999) The effect of bladder training, pelvic floor muscle training, or combination training on urodynamic parameters in women with urinary incontinence. Continence Program for Women Research Group. Neurourol Urodyn 18:427-36
Wyman, J F; Fantl, J A; McClish, D K et al. (1998) Comparative efficacy of behavioral interventions in the management of female urinary incontinence. Continence Program for Women Research Group. Am J Obstet Gynecol 179:999-1007
Bump, R C; Hurt, W G; Addison, W A et al. (1998) Reliability and correlation of measurements during and after bladder neck surgery. The Continence Program for Women Research Group. Br J Urol 82:628-33
Theofrastous, J P; Wyman, J F; Bump, R C et al. (1997) Relationship between urethral and vaginal pressures during pelvic muscle contraction. The Continence Program for Women Research Group. Neurourol Urodyn 16:553-8
Fantl, J A; Bump, R C; Robinson, D et al. (1996) Efficacy of estrogen supplementation in the treatment of urinary incontinence. The Continence Program for Women Research Group. Obstet Gynecol 88:745-9
Bump, R C; Hurt, W G; Theofrastous, J P et al. (1996) Randomized prospective comparison of needle colposuspension versus endopelvic fascia plication for potential stress incontinence prophylaxis in women undergoing vaginal reconstruction for stage III or IV pelvic organ prolapse. The Continence Program for W Am J Obstet Gynecol 175:326-33;discussion 333-5

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