Abstract

A center for immunologic research in disease is proposed which will use recently developed techniques for the study of mediators from mast cells and basophils to explore a variety of allergic and inflammatory conditions. Individual projects propose to study: 1. Mediator release in inflammatory bowel disease, 2. Proteases in bullous pemphigoid and chronic urticaria, 3. Mechanisms of anti-inflammatory actions of corticosteroids, 4. The production and modulation of arachidonic acid metabolites by purified human lung mast cells and macrophages, 5. The pathogenesis and treatment of allergic rhinitis and non-allergic rhinitis, 6. Regulation of acute airways reactions in lung disease including asthma, 7. Natural history of insect allergy, 8. Cyclooxygenase metabolites in human lung anaphylaxis, 9. Macrophages and immunologically mediated inflammation, 10. Effect of medical intervention of social and emotional cost of insect sting allergy in children, 11. Prevalence of sub-optimal immunotherapy for aeroallergen disease.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01AI031867-02
Application #
3547881
Study Section
Special Emphasis Panel (SRC (86))
Project Start
1991-09-01
Project End
1995-08-31
Budget Start
1992-09-01
Budget End
1993-08-31
Support Year
2
Fiscal Year
1992
Total Cost
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Laube, B L; Edwards, A M; Dalby, R N et al. (1998) The efficacy of slow versus faster inhalation of cromolyn sodium in protecting against allergen challenge in patients with asthma. J Allergy Clin Immunol 101:475-83
Schwiebert, L M; Mooney, J L; Van Horn, S et al. (1997) Identification of novel inducible genes in airway epithelium. Am J Respir Cell Mol Biol 17:106-13
Nyhan, D P; Shampaine, E L; Hirshman, C A et al. (1996) Single doses of intravenous protamine result in the formation of protamine-specific IgE and IgG antibodies. J Allergy Clin Immunol 97:991-7
Siler, D J; Cornish, K; Hamilton, R G (1996) Absence of cross-reactivity of IgE antibodies from subjects allergic to Hevea brasiliensis latex with a new source of natural rubber latex from guayule (Parthenium argentatum). J Allergy Clin Immunol 98:895-902
Branch, A D; Polaskova, J A (1995) 3-D models of the antigenomic ribozyme of the hepatitis delta agent with eight new contacts suggested by sequence analysis of 188 cDNA clones. Nucleic Acids Res 23:4180-9
Branch, A D; Levine, B J; Polaskova, J A (1995) An RNA tertiary structure of the hepatitis delta agent contains UV-sensitive bases U-712 and U-865 and can form in a bimolecular complex. Nucleic Acids Res 23:491-9
Peebles Jr, R S; Liu, M C; Lichtenstein, L M et al. (1995) IgA, IgG and IgM quantification in bronchoalveolar lavage fluids from allergic rhinitics, allergic asthmatics, and normal subjects by monoclonal antibody-based immunoenzymetric assays. J Immunol Methods 179:77-86
Hamilton, R G; Charous, B L; Adkinson Jr, N F et al. (1994) Serologic methods in the laboratory diagnosis of latex rubber allergy: study of nonammoniated, ammoniated latex, and glove (end-product) extracts as allergen reagent sources. J Lab Clin Med 123:594-604
Hubbard, W C; Bickel, C; Schleimer, R P (1994) Simultaneous quantitation of endogenous levels of cortisone and cortisol in human nasal and bronchoalveolar lavage fluids and plasma via gas chromatography-negative ion chemical ionization mass spectrometry. Anal Biochem 221:109-17
Branch, A D; Lee, S E; Neel, O D et al. (1993) Prominent polypurine and polypyrimidine tracts in plant viroids and in RNA of the human hepatitis delta agent. Nucleic Acids Res 21:3529-35

Showing the most recent 10 out of 11 publications