Abstract

This is the renewal of the Women s and Infants Transmission Study at the University of Puerto Rico, Medical Sciences Campus. This application is for the fourth 5-year funding cycle. Accomplishments include the enrollment of the highest number of unique mother-infant pairs among the sites, the highest number of pregnant women and infants, the second highest number of deliveries, and a significant contribution of samples for the national or central WITS repository. Scientific accomplishments include the first comprehensive description of HIV disease progression in infants enrolled in the WITS; a consultative role in the CDC and PHS sponsored recommendations for the Prevention of Perinatal Transmission of HIV; CDC Disease Progression of Classification or staging for HIV infected infants; standardization and training of the neurological exam performed in WITS; and the reproductive choices of women enrolled in WITS. The WITS program in Puerto Rico has achieved a profound impact as a model program extended island wide for the prevention of perinatal transmission of HIV. Since September 1996 all infants born to women enrolled in the program have been free of HIV infection.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01AI034858-12
Application #
6759398
Study Section
Special Emphasis Panel (ZAI1-GLM-A (M2))
Program Officer
Rosario, Joana A
Project Start
1993-07-01
Project End
2006-05-31
Budget Start
2004-06-01
Budget End
2005-05-31
Support Year
12
Fiscal Year
2004
Total Cost
$858,803
Indirect Cost

  Institution

Name
University of Puerto Rico Med Sciences
Department
Pediatrics
Type
Schools of Medicine
DUNS #
948108063
City
San Juan
State
PR
Country
United States
Zip Code
00936

  Publications

Ouyang, David W; Brogly, Susan B; Lu, Ming et al. (2010) Lack of increased hepatotoxicity in HIV-infected pregnant women receiving nevirapine compared with other antiretrovirals. AIDS 24:109-14
Paredes, Roger; Cheng, Irene; Kuritzkes, Daniel R et al. (2010) Postpartum antiretroviral drug resistance in HIV-1-infected women receiving pregnancy-limited antiretroviral therapy. AIDS 24:45-53
Watts, D H; Lu, M; Thompson, B et al. (2009) Treatment interruption after pregnancy: effects on disease progression and laboratory findings. Infect Dis Obstet Gynecol 2009:456717
Ouyang, David W; Shapiro, David E; Lu, Ming et al. (2009) Increased risk of hepatotoxicity in HIV-infected pregnant women receiving antiretroviral therapy independent of nevirapine exposure. AIDS 23:2425-30
Aldrovandi, Grace M; Chu, Clara; Shearer, William T et al. (2009) Antiretroviral exposure and lymphocyte mtDNA content among uninfected infants of HIV-1-infected women. Pediatrics 124:e1189-97
Mekmullica, Jutarat; Brouwers, Pim; Charurat, Manhattan et al. (2009) Early immunological predictors of neurodevelopmental outcomes in HIV-infected children. Clin Infect Dis 48:338-46
Dowd, Kimberly A; Hershow, Ronald C; Yawetz, Sigal et al. (2008) Maternal neutralizing antibody and transmission of hepatitis C virus to infants. J Infect Dis 198:1651-5
Pahwa, Savita; Read, Jennifer S; Yin, Wanrong et al. (2008) CD4+/CD8+ T cell ratio for diagnosis of HIV-1 infection in infants: Women and Infants Transmission Study. Pediatrics 122:331-9
Chen, Katherine T; Tuomala, Ruth E; Chu, Clara et al. (2008) No association between antepartum serologic and genital tract evidence of herpes simplex virus-2 coinfection and perinatal HIV-1 transmission. Am J Obstet Gynecol 198:399.e1-5
Mellins, C A; Chu, C; Malee, K et al. (2008) Adherence to antiretroviral treatment among pregnant and postpartum HIV-infected women. AIDS Care 20:958-68

Showing the most recent 10 out of 55 publications