The proposed research will investigate the role of Beta-carotene as a lung cancer preventive agent. A high risk cohort of men occupationally exposed to asbestos and a selected group of hospital patients with abnormal sputum cytopathology will be used for a randomized clinical trial of Beta-carotene versus placebo. Bronchial epithelial changes, evaluated by repeated sputum cytology, will be used as the measure of response to the chemopreventive agent. Serum levels of Beta-carotene will be studied with respect to the degree of sputum metaplasia or dysplasia found at initial examination and with respect to bronchial epithelial changes throughout the clinical trial.
| McLarty, J W; Holiday, D B; Girard, W M et al. (1995) Beta-Carotene, vitamin A, and lung cancer chemoprevention: results of an intermediate endpoint study. Am J Clin Nutr 62:1431S-1438S |
| Holiday, D B; McLarty, J W; Yanagihara, R H et al. (1995) Two biochemical markers effectively used to separate smokeless tobacco users from smokers and nonusers. South Med J 88:1107-13 |
| Holiday, D B; McLarty, J W; Farley, M L et al. (1995) Sputum cytology within and across laboratories. A reliability study. Acta Cytol 39:195-206 |
| Holiday, D B; McLarty, J W (1994) Identifying disagreement in ordinal ratings within a fixed panel of cytotechnologists. Anal Quant Cytol Histol 16:381-92 |
