Abstract

BirthdefectsaretheleadingcauseofinfantmortalityintheUS.Birthdefectsalsohaveenormousassociated emotionalandfiscalcosts.TheCaliforniaCenter?sresearchefforts,bothindependentlyandincollaboration withotherCentersforBirthDefectsResearchandPreventioncontributingtotheNationalBirthDefects PreventionStudy(NBDPS)andtheBirthDefectsStudytoEvaluatePregnancyExposuresI(BD-STEPSI) havebeenattheforefrontofpublichealthbirthdefectsresearch.Withthisnewfundingopportunity(BD- STEPSII),ourCenterwillfurtherenhancescientificunderstandingofthepotentialcausesofspecificbirth defects,whichwillundoubtedlyhaveimportantimplicationsforriskassessmentandpreventionofcommon, costly,anddeadlybirthdefects.Inthisapplicationweproposethefollowingaims:
Aim1 :EnhancetheepidemiologicpublichealthresearchcapacityoftheCentersforBirthDefectsand ResearchandPreventionbyactivelyparticipatinginBD-STEPSIIinaregionoftheUSthatishighlydiversein itsrace/ethnicityaswellitsenvironmentalexposures.
Aim2 :UtilizedatafromBD-STEPSIandIIaswellasNBDPS(andlikelyotherdatasourcesuniqueto California)toconductrigorouscollaborativeandlocalstudiesthatwillidentifypotentialmodifiableriskfactors forselectedbirthdefects(andwhereappropriate,incombinationwithgeneticsusceptibility)toreducethe publichealthburdenofbirthdefectsintheUS. TheCaliforniaCenteriswell-equippedtocontributetoBD-STEPSII?itisaworldleaderinbirthdefects epidemiologyandhighlyexperiencedinthedevelopment,datacollectionanddisseminationofinformationfrom population-basedstudiesofbirthdefects,exemplifiedbyitsoutstandingperformancewithintheCDCCenters forBirthDefectsResearchanditshighlyinnovativeresearchportfolio.Theapplicationdescribeshowthe CaliforniaCenterwillaccomplishAims1and2andwilltherebyfurthertheknowledgebaseaboutcausesand preventionforhumanbirthdefects.TheCaliforniaCenterhasextensiveexperienceconductingresearch relatedtotheBD-STEPSIIareasoffocus,whichincludematernalchronicdiseasesandtheirtreatment, infectiousdiseaseinpregnancy,andmedications.Wehaveproposedseveralanalyticinquiries, complementedbytheuseofadditionalinnovativedatasetsandanalyticapproaches,whichwillenableusto collaborativelycontinueelucidatingthecontributionoftheseandothermodifiableriskfactorstobirthdefects.

Public Health Relevance

BirthdefectsaretheleadingcauseofinfantmortalityintheUS.Birthdefectsalsohaveenormousassociated emotionalandfiscalcosts.Withthisnewfundingopportunity(BD-STEPSII),theCaliforniaCenter,both independentlyandincollaborationwithotherCenters,willconductstudiesthatwillidentifypotentialmodifiable riskfactorsforselectedbirthdefectstoreducethepublichealthburdenofbirthdefectsintheUS.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Centers for Disease Control and Prevention (NCBDD)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01DD001226-03
Application #
9973033
Study Section
Special Emphasis Panel (ZDD1)
Project Start
2018-09-01
Project End
2021-08-31
Budget Start
2020-09-01
Budget End
2021-08-31
Support Year
3
Fiscal Year
2020
Total Cost
Indirect Cost

  Institution

Name
Stanford University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94305