The goal of this proposal is to establish the University of California, San Diego (UCSD) as one of the Continence Treatment Centers (CTC) in the Urinary Incontinence Treatment Network (UITN). As a member of the UITN, UCSD will collaborate with the other centers in the Network to assess the short and long-term outcomes of the multiple therapeutic modalities utilized in the treatment of women with stress and mixed urinary incontinence and participate in the enrollment of patients and data into any databases which may be developed. The treatment of women with stress and mixed urinary incontinence includes observation, behavioral, medical and surgical therapies. The indications for which of these therapies should be used for which type of patients varies greatly both regionally and between physicians in different specialties. There are few scientifically rigorous studies that evaluate the outcomes of these therapies, their morbidity and the effects they have on quality of life and other pelvic floor functions. In fact, each year more therapeutic options are offered without comparing them to any set standard. The UITN will have as a secondary goal the establishment of standardized definitions, evaluation and quality of life measurements. Vital to the success of this endeavor is the recruitment of a sufficient number of patients, establishment of a standardized protocol for evaluation and follow-up.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01DK060401-02
Application #
6524635
Study Section
Special Emphasis Panel (ZDK1-GRB-4 (M2))
Program Officer
Kusek, John W
Project Start
2001-09-01
Project End
2005-06-30
Budget Start
2002-09-01
Budget End
2003-06-30
Support Year
2
Fiscal Year
2002
Total Cost
$198,427
Indirect Cost
Name
University of California San Diego
Department
Surgery
Type
Schools of Medicine
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Thomas-White, Krystal J; Kliethermes, Stephanie; Rickey, Leslie et al. (2017) Evaluation of the urinary microbiota of women with uncomplicated stress urinary incontinence. Am J Obstet Gynecol 216:55.e1-55.e16
Norton, Peggy A; Nager, Charles W; Brubaker, Linda et al. (2016) The cost of preoperative urodynamics: A secondary analysis of the ValUE trial. Neurourol Urodyn 35:81-4
Zimmern, Philippe E; Gormley, E Ann; Stoddard, Anne M et al. (2016) Management of recurrent stress urinary incontinence after burch and sling procedures. Neurourol Urodyn 35:344-8
Mueller, Elizabeth R; Litman, Heather; Rickey, Leslie R et al. (2015) Comparison of flowrates and voided volumes during non-instrumented uroflowmetry and pressure-flow studies in women with stress incontinence. Neurourol Urodyn 34:549-53
Kenton, Kimberly; Stoddard, Anne M; Zyczynski, Halina et al. (2015) 5-year longitudinal followup after retropubic and transobturator mid urethral slings. J Urol 193:203-10
Guthrie, Katherine A; LaCroix, Andrea Z; Ensrud, Kristine E et al. (2015) Pooled Analysis of Six Pharmacologic and Nonpharmacologic Interventions for Vasomotor Symptoms. Obstet Gynecol 126:413-22
Sirls, Larry T; Tennstedt, Sharon; Brubaker, Linda et al. (2015) The minimum important difference for the International Consultation on Incontinence Questionnaire-Urinary Incontinence Short Form in women with stress urinary incontinence. Neurourol Urodyn 34:183-7
Zyczynski, Halina M; Albo, Michael E; Goldman, Howard B et al. (2015) Change in Overactive Bladder Symptoms After Surgery for Stress Urinary Incontinence in Women. Obstet Gynecol 126:423-30
Brubaker, Linda; Litman, Heather J; Kim, Hae-Young et al. (2015) Missing data frequency and correlates in two randomized surgical trials for urinary incontinence in women. Int Urogynecol J 26:1155-9
Zimmern, Philippe; Litman, Heather J; Nager, Charles W et al. (2014) Effect of aging on storage and voiding function in women with stress predominant urinary incontinence. J Urol 192:464-8

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