This limited competition renewal application is for the Turku/Finland Clinical Center of The Environmental Determinants of Diabates in the Young (TEDDY) study. The primary objective of this multi-center, multi- national epidemiological study is the identification of infectious agents, dietary factors, or other environmental exposures that are associated with increased risk of islet autoimmunity and type 1 diabates mellitus (T1D). Factors affecting specific phenotypic manifestations such as early age of onset or rate of progression, or which provide protection from the development of T1D will also be identified. TEDDY is an observational cohort study in which newborns who are less than 4.5 months of age and have high risk HLA genotypes and come from the general population, or carry HLA risk alleles and are first-degree relatives of patients affected with T1D will be enrolled. Six Clinical Centers in the United States and Europe will screen 361,588 newborns of which it is anticipated that 17,804 will be eligible for enrollment, with just over 7,800 followed. Recruitment started in September 2004 and will continue until December 31, 2009. Participants will be followed to the age of 15 years. Identification of such etiologically important factors will lead to a better understanding of disease pathogenesis and result in new strategies to prevent, delay or reverse T1D.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01DK063863-09
Application #
8094457
Study Section
Special Emphasis Panel (ZDK1-GRB-G (J1))
Program Officer
Spain, Lisa M
Project Start
2003-04-01
Project End
2013-04-30
Budget Start
2011-05-01
Budget End
2012-04-30
Support Year
9
Fiscal Year
2011
Total Cost
$292,370
Indirect Cost
Name
Hospital District of Southwest Finland
Department
Type
DUNS #
368919671
City
Turku
State
Country
Finland
Zip Code
FI-20-521
Salami, Falastin; Lee, Hye-Seung; Freyhult, Eva et al. (2018) Reduction in White Blood Cell, Neutrophil, and Red Blood Cell Counts Related to Sex, HLA, and Islet Autoantibodies in Swedish TEDDY Children at Increased Risk for Type 1 Diabetes. Diabetes 67:2329-2336
Smith, Laura B; Liu, Xiang; Johnson, Suzanne Bennett et al. (2018) Family adjustment to diabetes diagnosis in children: Can participation in a study on type 1 diabetes genetic risk be helpful? Pediatr Diabetes 19:1025-1033
Uusitalo, Ulla; Lee, Hye-Seung; Andrén Aronsson, Carin et al. (2018) Early Infant Diet and Islet Autoimmunity in the TEDDY Study. Diabetes Care 41:522-530
Pitchika, Anitha; Vehik, Kendra; Hummel, Sandra et al. (2018) Associations of Maternal Diabetes During Pregnancy with Overweight in Offspring: Results from the Prospective TEDDY Study. Obesity (Silver Spring) 26:1457-1466
Riikonen, Anne; Hadley, David; Uusitalo, Ulla et al. (2018) Milk feeding and first complementary foods during the first year of life in the TEDDY study. Matern Child Nutr 14:e12611
Elding Larsson, Helena; Lynch, Kristian F; Lönnrot, Maria et al. (2018) Pandemrix® vaccination is not associated with increased risk of islet autoimmunity or type 1 diabetes in the TEDDY study children. Diabetologia 61:193-202
Koletzko, Sibylle; Lee, Hye-Seung; Beyerlein, Andreas et al. (2018) Cesarean Section on the Risk of Celiac Disease in the Offspring: The Teddy Study. J Pediatr Gastroenterol Nutr 66:417-424
Stanfill, Bryan A; Nakayasu, Ernesto S; Bramer, Lisa M et al. (2018) Quality Control Analysis in Real-time (QC-ART): A Tool for Real-time Quality Control Assessment of Mass Spectrometry-based Proteomics Data. Mol Cell Proteomics 17:1824-1836
Lynch, Kristian F; Lee, Hye-Seung; Törn, Carina et al. (2018) Gestational respiratory infections interacting with offspring HLA and CTLA-4 modifies incident ?-cell autoantibodies. J Autoimmun 86:93-103
Stewart, Christopher J; Ajami, Nadim J; O'Brien, Jacqueline L et al. (2018) Temporal development of the gut microbiome in early childhood from the TEDDY study. Nature 562:583-588

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