Abstract

This study addresses the MAPP Research Network requirements for an epidemiological study and an examination of the genetic contributions to one of the conditions termed """"""""urologic chronic pelvic pain syndromes"""""""" (UCPPS) by the MAPP initiative. Our objective in designing this project, and the University of Washington (UW) Discovery Center as a wholejs to enhance the growing body of knowledge about UCPPS by using a focused yet integrated multidisciplinary approach. Our approach will provide critical knowledge about the underlying genetic and environmental factors that promote CP/CPPS and its primary symptom of pain. One strength of this project is its response to multiple Research Priorities outlined in the MAPP RFA. Our primary aim is to determine the heritability of CP/CPPS by using genetic epidemiological strategies. A secondary aim is to address the phenotypic characteristics of CP/CPPS by examining current and historical demographic and psychosocial characteristics, psychiatric symptoms, and functional status. By identifying a cohort of middleaged twins with CP/CPPS, we also will set the stage for future projects that more comprehensively examine genetic and physiological factors in this cohort.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01DK082325-03
Application #
8137279
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
2010-07-01
Budget End
2011-06-30
Support Year
3
Fiscal Year
2010
Total Cost
$102,435
Indirect Cost

  Institution

Name
University of Washington
Department
Type
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Sutcliffe, Siobhan; Jemielita, Thomas; Lai, H Henry et al. (2018) A Case-Crossover Study of Urological Chronic Pelvic Pain Syndrome Flare Triggers in the MAPP Research Network. J Urol 199:1245-1251
Yang, Claire C; Miller, Jane L; Omidpanah, Adam et al. (2018) Physical Examination for Men and Women With Urologic Chronic Pelvic Pain Syndrome: A MAPP (Multidisciplinary Approach to the Study of Chronic Pelvic Pain) Network Study. Urology 116:23-29
Clemens, J Quentin; Stephens-Shields, Alisa; Naliboff, Bruce D et al. (2018) Correlates of Health Care Seeking Activities in Patients with Urological Chronic Pelvic Pain Syndromes: Findings from the MAPP Cohort. J Urol 200:136-140
Schrepf, Andrew; Naliboff, Bruce; Williams, David A et al. (2018) Adverse Childhood Experiences and Symptoms of Urologic Chronic Pelvic Pain Syndrome: A Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network Study. Ann Behav Med 52:865-877
Naliboff, Bruce D; Stephens, Alisa J; Lai, H Henry et al. (2017) Clinical and Psychosocial Predictors of Urological Chronic Pelvic Pain Symptom Change in 1 Year: A Prospective Study from the MAPP Research Network. J Urol 198:848-857
Kutch, Jason J; Labus, Jennifer S; Harris, Richard E et al. (2017) Resting-state functional connectivity predicts longitudinal pain symptom change in urologic chronic pelvic pain syndrome: a MAPP network study. Pain 158:1069-1082
Kutch, Jason J; Ichesco, Eric; Hampson, Johnson P et al. (2017) Brain signature and functional impact of centralized pain: a multidisciplinary approach to the study of chronic pelvic pain (MAPP) network study. Pain 158:1979-1991
Godfrey, Kathryn M; Herbert, Matthew; Strachan, Eric et al. (2017) Dexamethasone-suppressed Salivary Cortisol and Pain Sensitivity in Female Twins. Clin J Pain 33:246-253
Gasperi, Marianna; Krieger, John N; Forsberg, Christopher et al. (2017) Chronic prostatitis and comorbid non-urological overlapping pain conditions: A co-twin control study. J Psychosom Res 102:29-33
Lai, H Henry; Jemielita, Thomas; Sutcliffe, Siobhan et al. (2017) Characterization of Whole Body Pain in Urological Chronic Pelvic Pain Syndrome at Baseline: A MAPP Research Network Study. J Urol 198:622-631

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