The Adolescent Trial Unit at The Children's Hospital of Philadelphia (CHOP) seeks to continue their work in the Adolescent Medicine Trials Network for HIV/AIDS Interventions. Our major objectives are to continue to conduct clinical studies developed or co-endorsed by the ATN that will focus on the following: 1) primary prevention through the C2P infrastructure utilizing existing community collaborations, helping to identify HIV+ youth and linking them to care. 2.) secondary prevention through ATN clinical trials including therapeutic and behavioral interventions. 3.) tertiary prevention through ATN clinical trials including therapeutic and behavioral trials targeting infected youth. The site will accomplish these objectives as follows. The Connect to Protect project will continue to build on their community collaborations through participation in ATN 095, ATN 093, ATN 096 and ATN 066b. In order to accomplish the second and third objectives, the site will recruit and retain HIV-infected and at risk youth into clinical trials by targeted outreach through ATN 093 with the DOH and ATN 096 as well as through the Adolescent Initiative clinical program that works to identify HIV + youth and link them to care. Through the Adolescent Initiative, the site will provide a broad array of targeted multidisciplinary services to support youth once engaged in care and research. The site PI and ATN investigators will continue to work with the leadership groups and protocol teams such as ATN 069, ATN 071, ATN 061, ATN 080, ATN 072, and ATN 094 to develop and implement the agenda of the network. Other staff will support the research agenda through participation in the ATP, SCG and CCG. Finally, the site will contribute to the Network management through active participation in conference calls and biannual meetings.

Public Health Relevance

The impact of the HIV epidemic on the Philadelphia community continues to challenge our institution to honestly address the myriad of issues that affect the health and well being of our youth who are HIV infected and at risk for infection. This project addresses the epidemic of HIV infection in adolescents and young adults to provide much needed scientific data to prevent new infections by enhancing community research.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Research Project--Cooperative Agreements (U01)
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Special Emphasis Panel (ZHD1-DSR-A (15))
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Russo, Denise
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Children's Hospital of Philadelphia
United States
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Rudy, Bret J; Kapogiannis, Bill G; Worrell, Carol et al. (2015) Immune Reconstitution but Persistent Activation After 48 Weeks of Antiretroviral Therapy in Youth With Pre-Therapy CD4 >350 in ATN 061. J Acquir Immune Defic Syndr 69:52-60
McGuire, Jennifer L; Gill, Alexander J; Douglas, Steven D et al. (2015) Central and peripheral markers of neurodegeneration and monocyte activation in HIV-associated neurocognitive disorders. J Neurovirol 21:439-48
McGuire, Jennifer L; Kempen, John H; Localio, Russell et al. (2015) Immune markers predictive of neuropsychiatric symptoms in HIV-infected youth. Clin Vaccine Immunol 22:27-36
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McGuire, Jennifer L; Barrett, Jeffrey S; Vezina, Heather E et al. (2014) Adjuvant therapies for HIV-associated neurocognitive disorders. Ann Clin Transl Neurol 1:938-52
Outlaw, Angulique Y; Naar-King, Sylvie; Tanney, Mary et al. (2014) The initial feasibility of a computer-based motivational intervention for adherence for youth newly recommended to start antiretroviral treatment. AIDS Care 26:130-5
Naar-King, Sylvie; Outlaw, Angulique Y; Sarr, Moussa et al. (2013) Motivational Enhancement System for Adherence (MESA): pilot randomized trial of a brief computer-delivered prevention intervention for youth initiating antiretroviral treatment. J Pediatr Psychol 38:638-48
Tanney, Mary R; Naar-King, Sylvie; MacDonnel, Karen et al. (2012) Depression and stigma in high-risk youth living with HIV: a multi-site study. J Pediatr Health Care 26:300-5
Castillo, Marné; Palmer, Brett J; Rudy, Bret J et al. (2012) Creating partnerships for HIV prevention among YMSM: the Connect Protect® Project and House and Ball Community in Philadelphia. J Prev Interv Community 40:165-75
Reed, Sarah J; Miller, Robin Lin; Francisco, Vincent T et al. (2012) Programmatic capacity and HIV structural change interventions: influences on coalitions' success and efficiency in accomplishing intermediate outcomes. J Prev Interv Community 40:118-30

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