The purpose of this study is to test the efficacy, feasibility and safety of dietary intervention in pre-adolescent children with elevated LDL-cholesterol (LDL-C) levels. Participants recruited from referrals from a large network of pediatricians and cardiologists will be randomly assigned to either the usual or special care group to evaluate LDL-C response to non-pharmacologic nutritional intervention. Based on the recommendations of the American Heart Association and the NIH Consensus Panel, participants will be guided toward maximum reduction in total fat, saturated fat and dietary cholesterol with compensatory increases in complex carbohydrate and water soluble fiber. The eating pattern will emphasize fruits, vegetables, whole grains, low fat dairy products and lean animal protein sources. Sodium reduction will be encouraged. In addition, participants will be advised to perform regular aerobic activity and to achieve ideal weight for height. Nutritional status will be carefully monitored through biochemical, anthropometric and dietary assessments, to promote normal growth and development and to achieve optimal intake of essential nutrients. Psychosocial development will also be evaluated and strategies for coping with peer pressure and other obstacles to optimal nutrition in a relatively unsupportive modern society will be presented. Changes in LDL-C levels will be compared between the two groups from baseline to the end of the study to evaluate the effectiveness of intervention. These findings will help to determine whether children will have a sufficient clinical response to reduce their percentile rank on the plasma cholesterol distribution curve from greater than the 90th percentile to the 75th percentile or lower. Findings from this study will improve our understanding of the physiologic and behavioral effects of non-pharmacologic intervention to lower elevated lipid levels in children.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01HL037947-04
Application #
3552904
Study Section
Special Emphasis Panel (SRC (17))
Project Start
1986-12-04
Project End
1993-05-31
Budget Start
1990-02-01
Budget End
1991-01-31
Support Year
4
Fiscal Year
1990
Total Cost
Indirect Cost
Name
Northwestern University at Chicago
Department
Type
Schools of Medicine
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Egleston, Brian L; Chandler, D Walt; Dorgan, Joanne F (2010) Validity of estimating non-sex hormone-binding globulin bound testosterone and oestradiol from total hormone measurements in boys and girls. Ann Clin Biochem 47:233-41
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Gidding, Samuel S; Barton, Bruce A; Dorgan, Joanne A et al. (2006) Higher self-reported physical activity is associated with lower systolic blood pressure: the Dietary Intervention Study in Childhood (DISC). Pediatrics 118:2388-93
Dorgan, Joanne F; Hunsberger, Sally A; McMahon, Robert P et al. (2003) Diet and sex hormones in girls: findings from a randomized controlled clinical trial. J Natl Cancer Inst 95:132-41
Obarzanek, E; Kimm, S Y; Barton, B A et al. (2001) Long-term safety and efficacy of a cholesterol-lowering diet in children with elevated low-density lipoprotein cholesterol: seven-year results of the Dietary Intervention Study in Children (DISC). Pediatrics 107:256-64
Lavigne, J V; Brown, K M; Gidding, S et al. (1999) A cholesterol-lowering diet does not produce adverse psychological effects in children: three-year results from the dietary intervention study in children. Health Psychol 18:604-13

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