BARI will consist of a prospective randomized trial designed to compare the long-term efficacy of PTCA and CABG in clinical subsets of patients with multivessel coronary disease and severe angina, unstable angina or angina after acute MI, and a registry of all patients undergoing coronary angiography because of severe or unstable angina, with or without MI, at 12 participating clinical sites. Roughly 1,800 patients will be randomized to PTCA or CABG during the 24-month recruitment period and duration of follow-up will be a minimum of four years. Clinical and objective data will be collected for each subject in the registry and in the randomized trial at entry and during follow-up. The best choice of therapy is unclear at present for these large subsets of patients with severe coronary artery disease and the randomized trial should establish the relative merits of PTCA and CABG, namely the safety and rate of success of each procedure, recurrence rate of angina, need for re-intervention and occurrence of late coronary events, and help to determine which procedure should be applied first. The registry data will, among several objectives, assess the validity of extending the conclusions of the trial to a larger population of patients with severe angina and multivessel coronary disease.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Research Project--Cooperative Agreements (U01)
Project #
Application #
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Montreal Heart Institute
Zip Code
H1 1C8
Holmes Jr, David R; Kim, Lauren J; Brooks, Maria Mori et al. (2007) The effect of coronary artery bypass grafting on specific causes of long-term mortality in the Bypass Angioplasty Revascularization Investigation. J Thorac Cardiovasc Surg 134:38-46, 46.e1
BARI Investigators (2007) The final 10-year follow-up results from the BARI randomized trial. J Am Coll Cardiol 49:1600-6
Holper, Elizabeth M; Brooks, Maria Mori; Kim, Lauren J et al. (2007) Effects of heart failure and diabetes mellitus on long-term mortality after coronary revascularization (from the BARI Trial). Am J Cardiol 100:196-202
Kip, Kevin E; Alderman, Edwin L; Bourassa, Martial G et al. (2002) Differential influence of diabetes mellitus on increased jeopardized myocardium after initial angioplasty or bypass surgery: bypass angioplasty revascularization investigation. Circulation 105:1914-20
Schwartz, Leonard; Kip, Kevin E; Frye, Robert L et al. (2002) Coronary bypass graft patency in patients with diabetes in the Bypass Angioplasty Revascularization Investigation (BARI). Circulation 106:2652-8
Vander Salm, Thomas J; Kip, Kevin E; Jones, Robert H et al. (2002) What constitutes optimal surgical revascularization? Answers from the Bypass Angioplasty Revascularization Investigation (BARI). J Am Coll Cardiol 39:565-72
Bittner, Vera; Hardison, Regina; Kelsey, Sheryl F et al. (2002) Non-high-density lipoprotein cholesterol levels predict five-year outcome in the Bypass Angioplasty Revascularization Investigation (BARI). Circulation 106:2537-42
Gurm, Hitinder S; Whitlow, Patrick L; Kip, Kevin E et al. (2002) The impact of body mass index on short- and long-term outcomes inpatients undergoing coronary revascularization. Insights from the bypass angioplasty revascularization investigation (BARI). J Am Coll Cardiol 39:834-40
Berger, P B; Velianou, J L; Aslanidou Vlachos, H et al. (2001) Survival following coronary angioplasty versus coronary artery bypass surgery in anatomic subsets in which coronary artery bypass surgery improves survival compared with medical therapy. Results from the Bypass Angioplasty Revascularization Investigation J Am Coll Cardiol 38:1440-9
(2000) Seven-year outcome in the Bypass Angioplasty Revascularization Investigation (BARI) by treatment and diabetic status. J Am Coll Cardiol 35:1122-9

Showing the most recent 10 out of 23 publications