The overall goal of this proposal is to continue the ongoing PROSPECTIVE STUDY of high-risk adolescents and young adults from the COGA study to enhance our knowledge about genetic, behavioral and environmental risk factors that contribute to the development of heavy drinking, alcohol related problems, alcohol use disorders (AUDs), and related psychiatric conditions. The COGA study is unique in gathering important information from multiple domains across generations of well characterized, multi-ethnic families collected nationally. Data include psychiatric, electrophysiological, neuropsychological, environmental, and genetic factors gathered prospectively from families at high risk for AUDs and from comparison families. Parallel measures for these domains were gathered previously on the original proband parents and other biological relatives in addition to the adolescents and young adults who are the focus of our ongoing work. Data from the parental generation have been successfully used to identify numerous risk factors for heavier drinking and associated problems and have helped to identify genes related directiy to the risk for AUDs and associated characteristics (highest quantities consumed, craving, levels of response to alcohol). Our work has also identified genes that contribute to externalizing behaviors measured both through structured interviews and electrophysiological profiles. Thus, the proposed work presents the unique opportunity to observe the ways in which genetic variants, electrophysiological endophenotypes and behavioral characteristics identified In one generation may operate, in conjunction with the environment, during the developmental phases of adolescence and eariy adulthood of the next generation. This cross generational information may help identify additional behavioral and environmental characteristics associated with gene variation and other markers of risk, which in turn would enhance our understanding of a broader array of risk factors for AUDs.

National Institute of Health (NIH)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
Application #
Study Section
Special Emphasis Panel (ZAA1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Suny Downstate Medical Center
United States
Zip Code
Dick, Danielle M (2018) Commentary for Special Issue of Prevention Science ""Using Genetics in Prevention: Science Fiction or Science Fact?"" Prev Sci 19:101-108
Liu, Dungang; Zhang, Heping (2018) Residuals and Diagnostics for Ordinal Regression Models: A Surrogate Approach. J Am Stat Assoc 113:845-854
Glasheen, Cristie; Johnson, Eric O; Saccone, Nancy L et al. (2018) Is the Fagerström test for nicotine dependence invariant across secular trends in smoking? A question for cross-birth cohort analysis of nicotine dependence. Drug Alcohol Depend 185:127-132
Su, Jinni; Kuo, Sally I-Chun; Bucholz, Kathleen K et al. (2018) Understanding Mechanisms of Genetic Risk for Adolescent Internalizing and Externalizing Problems: The Mediating Role of Parenting and Personality. Twin Res Hum Genet 21:310-321
Hartz, Sarah M; Oehlert, Mary; Horton, A C et al. (2018) Daily Drinking Is Associated with Increased Mortality. Alcohol Clin Exp Res 42:2246-2255
Schuckit, Marc A; Smith, Tom L; Danko, George et al. (2018) A 22-Year Follow-Up (Range 16 to 23) of Original Subjects with Baseline Alcohol Use Disorders from the Collaborative Study on Genetics of Alcoholism. Alcohol Clin Exp Res 42:1704-1714
Schuckit, Marc A (2018) A Critical Review of Methods and Results in the Search for Genetic Contributors to Alcohol Sensitivity. Alcohol Clin Exp Res 42:822-835
Aliev, Fazil; Salvatore, Jessica E; Agrawal, Arpana et al. (2018) A Brief Critique of the TATES Procedure. Behav Genet 48:155-167
Smit, Dirk J A; Wright, Margaret J; Meyers, Jacquelyn L et al. (2018) Genome-wide association analysis links multiple psychiatric liability genes to oscillatory brain activity. Hum Brain Mapp 39:4183-4195
Cabana-Domínguez, Judit; Arenas, Concepció; Cormand, Bru et al. (2018) MiR-9, miR-153 and miR-124 are down-regulated by acute exposure to cocaine in a dopaminergic cell model and may contribute to cocaine dependence. Transl Psychiatry 8:173

Showing the most recent 10 out of 466 publications