The applicant, a participant in the current Herpetic eye Disease Study (BEDS), proposes to be a Regional Center for Phase II of the Herpetic Eye Disease Study. Phase II will consist of two randomized, double-masked clinical trials and a study of recurrent factors of herpetic eye disease. The first trial, HEDS-EKT, will compare acyclovir to placebo for the prevention or delay of subsequent stromal keratitis or iritis in patients with active herpetic epithelial keratitis. The second, HEDS-APT, will compare acyclovir to placebo for prolonging time to recurrence of herpetic eye disease in patients with an episode of any herpetic eye disease in the past year and who have been free of disease and off all treatment for the past month. The recurrence factors study (HEDS-RFS) will obtain data by questionnaire on stress, trauma, and other potential triggers of recurrence of herpetic disease for correlation with recurrence data from the two clinical trials. As a Regional Center, the applicant will be responsible for entering patients in the two clinical trials, and treating and following them according to protocol; entering consenting randomized patients into the triggers study; coordinating and overseeing the participation of 5 additional participating local sites in the APT and EKT trials; and participating in the governance of HEDS via participation on the Executive Committee.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
3U10EY009696-05S1
Application #
2605202
Study Section
Vision Research and Training Committee (VSN)
Project Start
1992-08-20
Project End
1998-07-31
Budget Start
1996-08-01
Budget End
1998-07-31
Support Year
5
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Baylor College of Medicine
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
074615394
City
Houston
State
TX
Country
United States
Zip Code
77030
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Wu, Tzu; Mitchell, Bradley; Carothers, Thomas et al. (2003) Molecular analysis of the pediatric ocular surface for fungi. Curr Eye Res 26:33-6
Wu, Tzu G; Wilhelmus, Kirk R; Mitchell, Bradley M (2003) Experimental keratomycosis in a mouse model. Invest Ophthalmol Vis Sci 44:210-6
Wilhelmus, Kirk R (2002) Indecision about corticosteroids for bacterial keratitis: an evidence-based update. Ophthalmology 109:835-42; quiz 843
Wilhelmus, K R (2001) The Draize eye test. Surv Ophthalmol 45:493-515
Wilhelmus, K R; Jones, D B (2001) Curvularia keratitis. Trans Am Ophthalmol Soc 99:111-30; discussion 130-2
Wilhelmus, K R (2000) The treatment of herpes simplex virus epithelial keratitis. Trans Am Ophthalmol Soc 98:505-32