Evidence from the scientific literature indicates that uncorrected astigmatism during childhood is associated with three types of amblyopia: (1) a difference in best-corrected acuity and contrast sensitivity for orthogonal gratings (meridional amblyopia or MA), (2) a difference in best-corrected acuity for orthogonally-oriented vernier acuity stimuli (also termed MA), and (3) a deficit in best-corrected recognition (letter) acuity. These data suggest the presence of a sensitive period for the development of astigmatism-related amblyopia. However, only limited information is available concerning factors that influence the development and treatment of astigmatism-related amblyopia. The lack of research regarding astigmatism-related amblyopia is most likely due to the low prevalence of astigmatism in most populations of children. However, a high prevalence of large amounts of astigmatism and astigmatism-related amblyopia has been documented in members of the Tohono O'Odham grade-school children are not currently wearing eyeglass correction. The presence of this large sample of uncorrected highly astigmatic children provides a unique opportunity for the study of the development and treatment of astigmatism-related amblyopia. The goals of the present study are: (1) to characterize vision deficits associated with astigmatism-related amblyopia (through measurements of grating acuity, vernier acuity, recognition acuity, and contrast sensitivity), (2) to identify factors influencing the development of astigmatism-related amblyopia (e.g., factors such as amount and type of astigmatism), and (3) to determine age-specific effects of glasses intervention on astigmatism-related amblyopia. The proposed study will provide valuable clinical information regarding the development and treatment of astigmatism-related amblyopia. In addition, it will provide a valuable public health service to members of the Tohono O'Odham.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10EY013153-04
Application #
6650734
Study Section
Special Emphasis Panel (ZEY1-VSN (01))
Program Officer
Everett, Donald F
Project Start
2000-09-15
Project End
2005-07-31
Budget Start
2003-08-01
Budget End
2004-07-31
Support Year
4
Fiscal Year
2003
Total Cost
$455,202
Indirect Cost
Name
University of Arizona
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
806345617
City
Tucson
State
AZ
Country
United States
Zip Code
85721
Harvey, Erin M; Leonard-Green, Tina K; Mohan, Kathleen M et al. (2017) Interrater and Test-Retest Reliability of the Beery Visual-Motor Integration in Schoolchildren. Optom Vis Sci 94:598-605
Mohan, Kathleen M; Miller, Joseph M; Harvey, Erin M et al. (2016) Assessment of Grating Acuity in Infants and Toddlers Using an Electronic Acuity Card: The Dobson Card. J Pediatr Ophthalmol Strabismus 53:56-9
Harvey, Erin M; Miller, Joseph M; Twelker, J Daniel et al. (2016) Reading Fluency in School-Aged Children with Bilateral Astigmatism. Optom Vis Sci 93:118-25
Davis, Amy L; Harvey, Erin M; Twelker, J Daniel et al. (2016) Convergence Insufficiency, Accommodative Insufficiency, Visual Symptoms, and Astigmatism in Tohono O'odham Students. J Ophthalmol 2016:6963976
Miller, Joseph M; Harvey, Erin M; Schwiegerling, Jim (2015) Higher-order aberrations and best-corrected visual acuity in Native American children with a high prevalence of astigmatism. J AAPOS 19:352-7.e1
Harvey, Erin M; Miller, Joseph M; Twelker, J Daniel et al. (2015) Longitudinal change and stability of refractive, keratometric, and internal astigmatism in childhood. Invest Ophthalmol Vis Sci 56:190-8
Crescioni, Mabel; Miller, Joseph M; Harvey, Erin M (2015) Accuracy of the Spot and Plusoptix photoscreeners for detection of astigmatism. J AAPOS 19:435-40
Crescioni, Mabel; Messer, Dawn H; Warholak, Terri L et al. (2014) Rasch analysis of the Student Refractive Error and Eyeglass Questionnaire. Optom Vis Sci 91:624-33
Harvey, Erin M; Miller, Joseph M; Schwiegerling, Jim et al. (2013) Developmental changes in anterior corneal astigmatism in Tohono O'odham Native American infants and children. Ophthalmic Epidemiol 20:102-8
Harvey, Erin M; Miller, Joseph M; Schwiegerling, Jim (2013) Utility of an open field Shack-Hartmann aberrometer for measurement of refractive error in infants and young children. J AAPOS 17:494-500

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