This is a competitive renewal application to continue our participation as a member of the Neonatal Research Network. The Women and Infants? Hospital/Brown University site has been a member of the Network during the past 2 cycles (completing year 10 in April, 2001 ). The application has detailed the productivity of this center during the past five years. We have also documented the productivity of our centers in other non-Network clinical and basic science research activities. Included in the application is a proposed protocol for submission to the Steering Committee for consideration. This protocol is entitled: """"""""Randomized Control Trial of Combined Sodium Restriction and Moderately Early Corticosteroid Treatment to Reduce the Incidence of Chronic Lung Disease in Extremely Low Birth Weight Infants. This is a 2 x 2 factorial design intention to treat trial that will test the hypothesis that sodium restriction in the first week of life will allow for a negative sodium balance, ensure physiologic contraction of extracellular body fluid, improves pulmonary function, less need for assisted ventilation and less risk for CLD. The other hypothesis is that moderately early use of CS will also reduce the incidence of CLD without significant serious side effects. The additional hypothesis is that a combination of the two interventions will have an """"""""add-on"""""""" effect in reducing the incidence of CLD. Success of this application will allow us to participate in a Network that will achieve the vision of NICHD in promoting collaborative clinical research to derive new knowledge to improve the quality of care for high- risk infants.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10HD027904-15
Application #
6895900
Study Section
Special Emphasis Panel (ZHD1-MCHG-B (10))
Program Officer
Higgins, Rosemary
Project Start
1991-04-01
Project End
2006-03-31
Budget Start
2005-04-01
Budget End
2006-03-31
Support Year
15
Fiscal Year
2005
Total Cost
$788,392
Indirect Cost
Name
Women and Infants Hospital-Rhode Island
Department
Type
DUNS #
069851913
City
Providence
State
RI
Country
United States
Zip Code
02905
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Jilling, Tamas; Ambalavanan, Namasivayam; Cotten, C Michael et al. (2018) Surgical necrotizing enterocolitis in extremely premature neonates is associated with genetic variations in an intergenic region of chromosome 8. Pediatr Res 83:943-953
Lin, Betty; Ostlund, Brendan D; Conradt, Elisabeth et al. (2018) Testing the programming of temperament and psychopathology in two independent samples of children with prenatal substance exposure. Dev Psychopathol 30:1023-1040
Bajaj, Monika; Natarajan, Girija; Shankaran, Seetha et al. (2018) Delivery Room Resuscitation and Short-Term Outcomes in Moderately Preterm Infants. J Pediatr 195:33-38.e2
Vohr, Betty R; Heyne, Roy; Bann, Carla et al. (2018) High Blood Pressure at Early School Age Among Extreme Preterms. Pediatrics 142:
Natarajan, Girija; Shankaran, Seetha; Laptook, Abbot R et al. (2018) Association between sedation-analgesia and neurodevelopment outcomes in neonatal hypoxic-ischemic encephalopathy. J Perinatol 38:1060-1067
Laptook, Abbot R; Bell, Edward F; Shankaran, Seetha et al. (2018) Admission Temperature and Associated Mortality and Morbidity among Moderately and Extremely Preterm Infants. J Pediatr 192:53-59.e2
Hintz, Susan R; Vohr, Betty R; Bann, Carla M et al. (2018) Preterm Neuroimaging and School-Age Cognitive Outcomes. Pediatrics 142:
Vohr, Betty R; Heyne, Roy; Bann, Carla M et al. (2018) Extreme Preterm Infant Rates of Overweight and Obesity at School Age in the SUPPORT Neuroimaging and Neurodevelopmental Outcomes Cohort. J Pediatr 200:132-139.e3
Askie, Lisa M; Darlow, Brian A; Finer, Neil et al. (2018) Association Between Oxygen Saturation Targeting and Death or Disability in Extremely Preterm Infants in the Neonatal Oxygenation Prospective Meta-analysis Collaboration. JAMA 319:2190-2201

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