This competing renewal application aims to demonstrate that the Floating Hospital for Children at Tufts Medical Center has the patient population, faculty and staff expertise, clinical services, research resources, and enrollment and follow-up successes to continue as an outstanding and productive member of the NICHD's Neonatal Research Network (NRN). Tufts has a long history of leadership in collaborative multicenter clinical research studies, as exemplified by one of the highest track records in the NRN for both enrollment (55%) and follow-up (97%) in the recently completed SUPPORT trial. Tufts draws upon an ethnically and geographically diverse neonatal population that receives its care in one of the largest level III nurseries in Boston. Approximately 600 infants (70% inborn) are admitted annually to its 41-bed NICU. In addition, both the Newborn Medicine and Maternal-Fetal Medicine programs have well-established affiliations with regional hospitals that result in referrals from a catchment area of 19,000 annual births. The Principal Investigator, Dr. Ivan D. Frantz III, and the Division of Newborn Medicine's faculty, have shown that they have the organizational strengths and research experience to design, implement, and actively participate in clinical trials. Our application is enhanced by an innovative concept application that incorporates a noninvasive genomic approach to explain the mechanisms underlying clinical variability in newborn infants of similar gestational ages and environmental exposures through analysis of salivary RNA. The Tufts program has broad institutional support and outstanding resources for the conduct of clinical research, data management and safety monitoring. Furthermore, the recent development of a Clinical Translational Science Institute (CTSI) at Tufts University and a Mother Infant Research Institute at Tufts Medical Center provide both infrastructure and additional collaborations.

Public Health Relevance

Through participation in multicenter studies, we will discover new approaches to care of high-risk infants that will result in decreased morbidity and mortality in this population. Such improvements will ultimately result in decreased expenditures for care and a decrease in the burden of disease both for individual patients and society.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
Application #
Study Section
Special Emphasis Panel (ZHD1-DSR-A (03))
Program Officer
Raju, Tonse N
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Tufts University
United States
Zip Code
Hintz, Susan R; Vohr, Betty R; Bann, Carla M et al. (2018) Preterm Neuroimaging and School-Age Cognitive Outcomes. Pediatrics 142:
Vohr, Betty R; Heyne, Roy; Bann, Carla M et al. (2018) Extreme Preterm Infant Rates of Overweight and Obesity at School Age in the SUPPORT Neuroimaging and Neurodevelopmental Outcomes Cohort. J Pediatr 200:132-139.e3
Askie, Lisa M; Darlow, Brian A; Finer, Neil et al. (2018) Association Between Oxygen Saturation Targeting and Death or Disability in Extremely Preterm Infants in the Neonatal Oxygenation Prospective Meta-analysis Collaboration. JAMA 319:2190-2201
Autmizguine, Julie; Tan, Sylvia; Cohen-Wolkowiez, Michael et al. (2018) Antifungal Susceptibility and Clinical Outcome in Neonatal Candidiasis. Pediatr Infect Dis J 37:923-929
Di Fiore, Juliann M; Martin, Richard J; Li, Hong et al. (2017) Patterns of Oxygenation, Mortality, and Growth Status in the Surfactant Positive Pressure and Oxygen Trial Cohort. J Pediatr 186:49-56.e1
Chawla, Sanjay; Natarajan, Girija; Shankaran, Seetha et al. (2017) Markers of Successful Extubation in Extremely Preterm Infants, and Morbidity After Failed Extubation. J Pediatr 189:113-119.e2
Puopolo, Karen M; Mukhopadhyay, Sagori; Hansen, Nellie I et al. (2017) Identification of Extremely Premature Infants at Low Risk for Early-Onset Sepsis. Pediatrics 140:
Peralta-Carcelen, Myriam; Carlo, Waldemar A; Pappas, Athina et al. (2017) Behavioral Problems and Socioemotional Competence at 18 to 22 Months of Extremely Premature Children. Pediatrics 139:
Younge, Noelle; Goldstein, Ricki F; Bann, Carla M et al. (2017) Survival and Neurodevelopmental Outcomes among Periviable Infants. N Engl J Med 376:617-628
Navarrete, Cristina T; Wrage, Lisa A; Carlo, Waldemar A et al. (2016) Growth Outcomes of Preterm Infants Exposed to Different Oxygen Saturation Target Ranges from Birth. J Pediatr 176:62-68.e4

Showing the most recent 10 out of 66 publications