Recent studies of mouse models of Marfan syndrome (MFS) have shown that devising a successful treatment for such a congenital disease requires an integrated and unbiased understanding of the network of reciprocal interactions among extracellular, signaling and intracellular molecules. It follows that a systematic and multidisciplinary examination of a broad range of connective tissue disorders (CTDs) in the NIAMS mission area (skin, bone and muscle) should be fruitful in accelerating discoveries of treatment of these diseases. Computational systems biology is an emerging powerful strategy that, combined with traditional biochemical, cellular and genetic approaches, can reveal novel regulatory principles. The proposed this meeting is therefore to bring together basic, translational and clinical researchers in the areas of extracellular matrix biology, TGF-2 signaling, CTD and systems biology to: 1. Assess the current state of knowledge in the relevant fields for applying systems biology approach to delineate fundamental disease mechanisms of connective tissues. 2. Explore the advantage and limitations of combining computational modeling predictions with structure-based drug design and high-throughput screening of small molecules for targeting specific CTDs. 3. Identify needs in new technical infrastructures, support initiatives and funding opportunities (RFAs and PAs) that can facilitate interactions among basic and clinical scientists, promote interdisciplinary research and expedite translational applications. Such a meeting will be the first to be held that attempts to integrate the themes of CTD pathogenesis, TGF-2 basic biology, small-molecule therapeutics and systems biology. .

Public Health Relevance

This meeting will provide a timely forum for the exchange, evaluation and integration of information concerning the challenge of applying the computational systems biology approach to the study of congenital and acquired CTD and the development of new therapeutic tools for these devastating and often lethal conditions

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Conference--Cooperative Agreements (U13)
Project #
1U13AR060691-01
Application #
8063338
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Program Officer
Tyree, Bernadette
Project Start
2010-09-06
Project End
2011-08-31
Budget Start
2010-09-06
Budget End
2011-08-31
Support Year
1
Fiscal Year
2010
Total Cost
$40,000
Indirect Cost
Name
Johns Hopkins University
Department
Genetics
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218