The Clinical Core, will serve as a reservoir of well-characterized study subjects, both patients and controls, for behavioral, clinical and basic research studies. As such, the Clinical Core will serve as the source of patients for Chronic Fatigue Syndrome Clinical Research Center (CFS CRC). This Core has 4 major specific aims 1) to prospectively evaluate and follow a referral clinic-based cohort of patients with chronic fatigue and CFS; 2) to utilize this population as the basis for investigations on CFS; 3) to maintain databases and banks of biological specimens on a variety fatigued and control populations and to recruit new comparison groups to improve our understanding of CFS; and 4) to examine the operating characteristics of clinical evaluation instruments already collected and patient subgroups using available data. The results of a comprehensive evaluation, including information on demographic, medical, psychological, functional and social features on almost 1,200 patients seen in a referral clinic are currently in our data base. Ethnic/racial minorities comprise about 8% and women 77% of patients. Information on new patients is entered weekly and patients are re- evaluated periodically. Control groups available for comparison to CFS patients include healthy individuals and those with medical disorders post-mononucleosis fatigue, the symptom of fatigue but not CFS, major depression, multiple chemical sensitivities, rheumatoid arthritis, fibromyalgia and temporomanidubular joint disorder. Besides descriptive studies, other questions amenable to study using the Clinical Core include the development of a battery of appropriate assessment measures for use in CFS and the evaluation of diagnostic tests or objective markers. In fact, the use of the Clinical Core resources has resulted in the development of a promising test for CFS and in the submission of 5 R01 and many other grant applications.

Project Start
2000-08-01
Project End
2001-07-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
6
Fiscal Year
2000
Total Cost
$138,185
Indirect Cost
Name
University of Washington
Department
Type
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
Mehalick, Melissa L; Schmaling, Karen B; Sabath, Daniel E et al. (2018) Longitudinal associations of lymphocyte subsets with clinical outcomes in chronic fatigue syndrome. Fatigue 6:80-91
Schmaling, Karen B; Betterton, Karran L (2016) Neurocognitive complaints and functional status among patients with chronic fatigue syndrome and fibromyalgia. Qual Life Res 25:1257-63
Romano, Joan M; Molton, Ivan R; Alschuler, Kevin N et al. (2016) Reported Pain and Fatigue Behaviors Mediate the Relationship Between Catastrophizing and Perceptions of Solicitousness in Patients With Chronic Fatigue. J Pain 17:328-35
Schmaling, Karen B; Romano, Joan M; Jensen, Mark P et al. (2015) Salivary cortisol responses to household tasks among couples with unexplained chronic fatigue. J Fam Psychol 29:296-301
Vitaliano, Peter P; Strachan, Eric; Dansie, Elizabeth et al. (2014) Does caregiving cause psychological distress? The case for familial and genetic vulnerabilities in female twins. Ann Behav Med 47:198-207
Poeschla, Brian; Strachan, Eric; Dansie, Elizabeth et al. (2013) Chronic fatigue and personality: a twin study of causal pathways and shared liabilities. Ann Behav Med 45:289-98
Dansie, Elizabeth J; Heppner, Pia; Furberg, Helena et al. (2012) The comorbidity of self-reported chronic fatigue syndrome, post-traumatic stress disorder, and traumatic symptoms. Psychosomatics 53:250-7
Dansie, Elizabeth J; Furberg, Helena; Afari, Niloofar et al. (2012) Conditions comorbid with chronic fatigue in a population-based sample. Psychosomatics 53:44-50
Wright, Lisa Johnson; Schur, Ellen; Noonan, Carolyn et al. (2010) Chronic pain, overweight, and obesity: findings from a community-based twin registry. J Pain 11:628-35
Smith, Mark S; Buchwald, Dedra S; Bogart, Andy et al. (2010) Adolescent offspring of mothers with chronic fatigue syndrome. J Adolesc Health 46:284-91

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