Goals: The virology core will provide virologic services including RT- PCR, Quantitative PCR (Q-PCR), human and rodent hantavirus antibody diagnosis, and neutralization assays for projects 1, 2, 3 and 4. The virology core will be situated in Chile but with supervisory input from Dr. Hjelle of UNM. The core will be a shared responsibility of Catholic University (CU) and the Institute of Public Health (ISP), a division of the Chilean Ministry of Health. It is anticipated that no core activities will be conducted at UNM, except in the context of training of Chilean investigators in the relevant techniques through the Fogarty or other mechanisms in the first year. UNM will also provide the SN virus isolated CC107 and clinical samples from patients with SN-HCPS for the comparative studies proposed in project 2.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Research Program--Cooperative Agreements (U19)
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Special Emphasis Panel (ZAI1)
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University of New Mexico
United States
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Armién, Blas; Ortiz, Paulo Lazaro; Gonzalez, Publio et al. (2016) Spatial-Temporal Distribution of Hantavirus Rodent-Borne Infection by Oligoryzomys fulvescens in the Agua Buena Region--Panama. PLoS Negl Trop Dis 10:e0004460
Gutiérrez-Tapia, Pablo; Palma, R Eduardo (2016) Integrating phylogeography and species distribution models: cryptic distributional responses to past climate change in an endemic rodent from the central Chile hotspot. Divers Distrib 22:638-650
Vial, Cecilia; Martinez-Valdebenito, Constanza; Rios, Susana et al. (2016) Molecular method for the detection of Andes hantavirus infection: validation for clinical diagnostics. Diagn Microbiol Infect Dis 84:36-39
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Manigold, Tobias; Vial, Pablo (2014) Human hantavirus infections: epidemiology, clinical features, pathogenesis and immunology. Swiss Med Wkly 144:w13937
Vial, Pablo A; Valdivieso, Francisca; Ferres, Marcela et al. (2013) High-dose intravenous methylprednisolone for hantavirus cardiopulmonary syndrome in Chile: a double-blind, randomized controlled clinical trial. Clin Infect Dis 57:943-51
Armien, Blas; Pascale, Juan M; Muñoz, Carlos et al. (2013) Hantavirus fever without pulmonary syndrome in Panama. Am J Trop Med Hyg 89:489-94
Schountz, Tony; Acuña-Retamar, Mariana; Feinstein, Shira et al. (2012) Kinetics of immune responses in deer mice experimentally infected with Sin Nombre virus. J Virol 86:10015-27

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