Abstract

The Resource core, under the direction of Dr. Mark Kaplan and assisted by Drs. Robert Tepper and Susan? Perkins, provides support to the Pis of the AADCRC in the following areas.? As the program described in this application depends extensively on mouse models of disease, we will? centralize efforts to breed, genotype and procure mice for Program studies. This will also allow coordination? of experiments to maximize the information gained by the Program by facilitating access to all investigators? in the Program. Thus the first three specific Aims are to:? 1. Breed and genotype mice for use in the Program.? 2. Procure mice required for the study? 3. Coordinate use of animals to maximize data obtained from minimal numbers of mice? This will include technical expertise (Tepper).? The core will also establish equipment for core usage to maximize the amount of information that can be? gained from experimental samples.? 4. Establish and maintain core equipment.? The core will also be the source of Biostatistical support through the role of Dr. Perkins. Thus, the final Aim? is to:? 5. Provide Biostatistical support for the Projects (Perkins).? Thus, the Resource Core is the foundation of a highly interactive Program and will help the investigators in? achieving the goal of a greater understanding of the pathogenesis of Atopic Dermatitis.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI070448-03
Application #
7645659
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2008-06-01
Budget End
2009-05-31
Support Year
3
Fiscal Year
2008
Total Cost
$105,941
Indirect Cost

  Institution

Name
Indiana University-Purdue University at Indianapolis
Department
Type
DUNS #
603007902
City
Indianapolis
State
IN
Country
United States
Zip Code
46202

  Publications

Chang, Daniel; Yao, Weiguo; Tiller, Christina J et al. (2015) Exhaled nitric oxide during infancy as a risk factor for asthma and airway hyperreactivity. Eur Respir J 45:98-106
Sarria, Edgar E; Mattiello, Rita; Yao, Weiguo et al. (2014) Atopy, cytokine production, and airway reactivity as predictors of pre-school asthma and airway responsiveness. Pediatr Pulmonol 49:132-9
Turner, Matthew J; Dasilva-Arnold, Sonia C; Yi, Qiaofang et al. (2013) Topical application of a vitamin D analogue exacerbates atopic dermatitis and induces the atopic dermatitis-like phenotype in Stat6VT mice. Pediatr Dermatol 30:574-8
Walline, Crystal C; Sehra, Sarita; Fisher, Amanda J et al. (2013) Allergic airway disease in mice alters T and B cell responses during an acute respiratory poxvirus infection. PLoS One 8:e62222
Spandau, Dan F; Lewis, Davina A; Somani, Ally-Khan et al. (2012) Fractionated laser resurfacing corrects the inappropriate UVB response in geriatric skin. J Invest Dermatol 132:1591-6
Travers, Jeffrey B; Kozman, Amal; Yao, Yongxue et al. (2012) Treatment outcomes of secondarily impetiginized pediatric atopic dermatitis lesions and the role of oral antibiotics. Pediatr Dermatol 29:289-96
Sawant, Deepali V; Sehra, Sarita; Nguyen, Evelyn T et al. (2012) Bcl6 controls the Th2 inflammatory activity of regulatory T cells by repressing Gata3 function. J Immunol 189:4759-69
DaSilva, Sonia C; Sahu, Ravi P; Konger, Raymond L et al. (2012) Increased skin barrier disruption by sodium lauryl sulfate in mice expressing a constitutively active STAT6 in T cells. Arch Dermatol Res 304:65-71
Byrne, A M; Goleva, E; Chouiali, F et al. (2012) Induction of GITRL expression in human keratinocytes by Th2 cytokines and TNF-?: implications for atopic dermatitis. Clin Exp Allergy 42:550-9
Stritesky, Gretta L; Muthukrishnan, Rajarajeswari; Sehra, Sarita et al. (2011) The transcription factor STAT3 is required for T helper 2 cell development. Immunity 34:39-49

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