The Administrative Core (A) proposed will provide administrative support for the four scientific projects and the clinical laboratory core (B) comprising this program entitled """"""""The University of Pittsburgh Medical Center Sexually Transmitted Infections Cooperative Research Center"""""""" (UPMC STI-CRC) and will be directed by Dr. Toni Darville. The administrative core will play an integral role in facilitating the integration of the projects proposed in this cooperative agreement program. In particular, a key attribute of the proposed UPMC STICRC involves the high degree of collaboration between the individual projects and cores that reflects the shared interest of the principal investigators in determining specific host and pathogenic mechanisms that contribute to the development of upper reproductive tract infections due to sexually transmitted organisms and endogenous microbes. The Administrative Core will: (1) Provide administrative oversight for the scientific conduct of each of the projects and cores, ensuring adequate integration and collaboration between the individual projects. (2) Provide fiscal oversight. (3) Interact with NIH representatives to implement strategic planning and ensure that reporting requirements to NIH are met. (4) Coordinate interactions with the biostatistics and data management services of the University of Pittsburgh Clinical and Translational Science Institute (CTSI). (5) Facilitate data sharing and intellectual property management. (6) Provide administrative/secretarial support to the UPMC STI-CRC. The Administrative Core will comprise the Center Director, Co-Center Director, and an administrative assistant.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Research Program--Cooperative Agreements (U19)
Project #
Application #
Study Section
Special Emphasis Panel (ZAI1-MMT-M)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Pittsburgh
United States
Zip Code
Zheng, Xiaojing; O'Connell, Catherine M; Zhong, Wujuan et al. (2018) Gene Expression Signatures Can Aid Diagnosis of Sexually Transmitted Infection-Induced Endometritis in Women. Front Cell Infect Microbiol 8:307
Zheng, Xiaojing; O'Connell, Catherine M; Zhong, Wujuan et al. (2018) Discovery of Blood Transcriptional Endotypes in Women with Pelvic Inflammatory Disease. J Immunol 200:2941-2956
Rahman, K Shamsur; Darville, Toni; Wiesenfeld, Harold C et al. (2018) Mixed Chlamydia trachomatis Peptide Antigens Provide a Specific and Sensitive Single-Well Colorimetric Enzyme-Linked Immunosorbent Assay for Detection of Human Anti-C. trachomatis Antibodies. mSphere 3:
Taylor, Brandie D; Zheng, Xiaojing; O'Connell, Catherine M et al. (2018) Risk factors for Mycoplasma genitalium endometritis and incident infection: a secondary data analysis of the T cell Response Against Chlamydia (TRAC) Study. Sex Transm Infect 94:414-420
Rahman, K Shamsur; Darville, Toni; Russell, Ali N et al. (2018) Comprehensive Molecular Serology of Human Chlamydia trachomatis Infections by Peptide Enzyme-Linked Immunosorbent Assays. mSphere 3:
Rahman, K Shamsur; Darville, Toni; Russell, Ali N et al. (2018) Discovery of Human-Specific Immunodominant Chlamydia trachomatis B Cell Epitopes. mSphere 3:
Taylor, Brandie D; Zheng, Xiaojing; Darville, Toni et al. (2017) Whole-Exome Sequencing to Identify Novel Biological Pathways Associated With Infertility After Pelvic Inflammatory Disease. Sex Transm Dis 44:35-41
Poston, Taylor B; Qu, Yanyan; Girardi, Jenna et al. (2017) A Chlamydia-Specific TCR-Transgenic Mouse Demonstrates Th1 Polyfunctionality with Enhanced Effector Function. J Immunol 199:2845-2854
Petrina, Melinda A B; Cosentino, Lisa A; Rabe, Lorna K et al. (2017) Susceptibility of bacterial vaginosis (BV)-associated bacteria to secnidazole compared to metronidazole, tinidazole and clindamycin. Anaerobe 47:115-119
Russell, Ali N; Zheng, Xiaojing; O'Connell, Catherine M et al. (2016) Identification of Chlamydia trachomatis Antigens Recognized by T Cells From Highly Exposed Women Who Limit or Resist Genital Tract Infection. J Infect Dis 214:1884-1892

Showing the most recent 10 out of 32 publications