This ICEMR program endeavors to achieve a better understanding of malaria epidemiology, vector biology, multidrug resistance, and circulation of falsified and substandard artemisinin-based combination therapies in the Greater Mekong Subregion of Southeast Asia. Our program focuses on malaria transmission along international borders in three strategically selected countries, China, Myanmar and Thailand, which have dramatically different malaria epidemiology. This program involves a large number of key investigators from multiple institutions from the U.S. and these three endemic countries, who will conduct malaria research at multiple study and sentinel surveillance sites in these countries. To meet this challenge, this administrative core is established to 1) provide administrative support for managing, coordinating, and supervising the research activities of this program to ensure that each project achieves its scientific goals; 2) provide an organizational management plan for financial and regulatory oversight; and 3) support linkages with funding agency, scientific advisory group, and outreach activities. We have developed an administrative structure and procedures for managing and coordinating all research and training activities. This administrative core will facilitate research-related activities of the program, assist in the organization of ICEMR-related meetings, and develop and submit annual progress and financial reports. In addition to the significant dedication of the program director and co-directors in the overall administration, we have also designated in-country coordinators to further enhance daily supervision and coordination of the scientific activities at the study sites. Through streamlined administration of the ICEMR, we aim to build a strong collaborative malaria research network to successfully meet the scientific goals of the program.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI089672-12
Application #
9915844
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2020-04-01
Budget End
2021-03-31
Support Year
12
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of South Florida
Department
Type
DUNS #
069687242
City
Tampa
State
FL
Country
United States
Zip Code
33617
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Zhong, Daibin; Koepfli, Cristian; Cui, Liwang et al. (2018) Molecular approaches to determine the multiplicity of Plasmodium infections. Malar J 17:172
Bunditvorapoom, Duangkamon; Kochakarn, Theerarat; Kotanan, Namfon et al. (2018) Fitness Loss under Amino Acid Starvation in Artemisinin-Resistant Plasmodium falciparum Isolates from Cambodia. Sci Rep 8:12622
Siddiqui, Faiza A; Cabrera, Mynthia; Wang, Meilian et al. (2018) Plasmodium falciparum Falcipain-2a Polymorphisms in Southeast Asia and Their Association With Artemisinin Resistance. J Infect Dis 218:434-442
Yang, Henglin; Wang, Jingyan; Liu, Hui et al. (2018) Randomized, Double-Blind, Placebo-Controlled Studies to Assess Safety and Prophylactic Efficacy of Naphthoquine-Azithromycin Combination for Malaria Prophylaxis in Southeast Asia. Antimicrob Agents Chemother 62:
Chaverra-Rodriguez, Duverney; Macias, Vanessa M; Hughes, Grant L et al. (2018) Targeted delivery of CRISPR-Cas9 ribonucleoprotein into arthropod ovaries for heritable germline gene editing. Nat Commun 9:3008
Mbenda, Huguette Gaelle Ngassa; Zeng, Weilin; Bai, Yao et al. (2018) Genetic diversity of the Plasmodium vivax phosphatidylinositol 3-kinase gene in two regions of the China-Myanmar border. Infect Genet Evol 61:45-52
Bai, Yao; Zhang, Jiaqi; Geng, Jinting et al. (2018) Longitudinal surveillance of drug resistance in Plasmodium falciparum isolates from the China-Myanmar border reveals persistent circulation of multidrug resistant parasites. Int J Parasitol Drugs Drug Resist 8:320-328
Zhao, Yan; Zeng, Jie; Zhao, Yonghong et al. (2018) Risk factors for asymptomatic malaria infections from seasonal cross-sectional surveys along the China-Myanmar border. Malar J 17:247
Miao, Jun; Chen, Zhao; Wang, Zenglei et al. (2017) Sex-Specific Biology of the Human Malaria Parasite Revealed from the Proteomes of Mature Male and Female Gametocytes. Mol Cell Proteomics 16:537-551

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