The proposed Center for Excellence in Translational Research combines 4 related endeavors focused in the development of a rapid molecular diagnostic with which to diagnosed first and second line drug resistance to Mycobacteria tuberculosis. The administrative core of this center provide scientific leadership and support for the center through the PI and Scientific Advisory Board consulting closely with the research project Pis and collaborators. The core will provide administrative support to each ofthe 4 research projects and the Sequencing core including negotiation, execution, and monitoring of sub-contracts and consulting agreements, financial monitoring and invoice tracking, communications platforms and plans including project website and portal for dissemination and storage of key center documents, teleconference/videoconference/web-conference infrastructure, centralized scheduling of teleconferences and meetings and travel and meeting logistics . The core will also provide continuous monitoring and evaluation ofthe progress ofthe projects through tracking of milestones and will ensure project regulatory compliance for human subjects, animal protocols and BSL3 biosafety standards. Lastly, the core will work with the Scientific Advisory Committee to solicit and review Supplementary projects aligned to the goals of the Center.

Public Health Relevance

By supporting the activities of this Center, the Administrative Core will contribute to the development of a rapid diagnostic test that will enable early diagnosis and appropriate treatment of drug resistant TB.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Research Program--Cooperative Agreements (U19)
Project #
Application #
Study Section
Special Emphasis Panel (ZAI1-LR-M (J1))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Harvard University
United States
Zip Code
Gong, Lingyan; Ouyang, Wei; Li, Zirui et al. (2018) Direct numerical simulation of continuous lithium extraction from high Mg2+/Li+ ratio brines using microfluidic channels with ion concentration polarization. J Memb Sci 556:34-41
Hicks, Nathan D; Yang, Jian; Zhang, Xiaobing et al. (2018) Clinically prevalent mutations in Mycobacterium tuberculosis alter propionate metabolism and mediate multidrug tolerance. Nat Microbiol 3:1032-1042
Linger, Yvonne; Knickerbocker, Christopher; Sipes, David et al. (2018) Genotyping Multidrug-Resistant Mycobacterium tuberculosis from Primary Sputum and Decontaminated Sediment with an Integrated Microfluidic Amplification Microarray Test. J Clin Microbiol 56:
Sakatos, Alexandra; Babunovic, Gregory H; Chase, Michael R et al. (2018) Posttranslational modification of a histone-like protein regulates phenotypic resistance to isoniazid in mycobacteria. Sci Adv 4:eaao1478
Thakore, Nitu; Norville, Ryan; Franke, Molly et al. (2018) Automated TruTip nucleic acid extraction and purification from raw sputum. PLoS One 13:e0199869
Thakore, Nitu; Garber, Steve; Bueno, Arial et al. (2018) A bench-top automated workstation for nucleic acid isolation from clinical sample types. J Microbiol Methods 148:174-180
Gong, Lingyan; Ouyang, Wei; Li, Zirui et al. (2017) Force fields of charged particles in micro-nanofluidic preconcentration systems. AIP Adv 7:125020
Yadon, Adam N; Maharaj, Kashmeel; Adamson, John H et al. (2017) A comprehensive characterization of PncA polymorphisms that confer resistance to pyrazinamide. Nat Commun 8:588
Calderón, R I; Velásquez, G E; Becerra, M C et al. (2017) Prevalence of pyrazinamide resistance and Wayne assay performance analysis in a tuberculosis cohort in Lima, Peru. Int J Tuberc Lung Dis 21:894-901
Rock, Jeremy M; Hopkins, Forrest F; Chavez, Alejandro et al. (2017) Programmable transcriptional repression in mycobacteria using an orthogonal CRISPR interference platform. Nat Microbiol 2:16274

Showing the most recent 10 out of 19 publications