The proposed Center for Excellence in Translational Research combines 4 related endeavors focused in the development of a rapid molecular diagnostic with which to diagnosed first and second line drug resistance to Mycobacteria tuberculosis. The administrative core of this center provide scientific leadership and support for the center through the PI and Scientific Advisory Board consulting closely with the research project Pis and collaborators. The core will provide administrative support to each ofthe 4 research projects and the Sequencing core including negotiation, execution, and monitoring of sub-contracts and consulting agreements, financial monitoring and invoice tracking, communications platforms and plans including project website and portal for dissemination and storage of key center documents, teleconference/videoconference/web-conference infrastructure, centralized scheduling of teleconferences and meetings and travel and meeting logistics . The core will also provide continuous monitoring and evaluation ofthe progress ofthe projects through tracking of milestones and will ensure project regulatory compliance for human subjects, animal protocols and BSL3 biosafety standards. Lastly, the core will work with the Scientific Advisory Committee to solicit and review Supplementary projects aligned to the goals of the Center.
By supporting the activities of this Center, the Administrative Core will contribute to the development of a rapid diagnostic test that will enable early diagnosis and appropriate treatment of drug resistant TB.
|Gong, Lingyan; Ouyang, Wei; Li, Zirui et al. (2018) Direct numerical simulation of continuous lithium extraction from high Mg2+/Li+ ratio brines using microfluidic channels with ion concentration polarization. J Memb Sci 556:34-41|
|Hicks, Nathan D; Yang, Jian; Zhang, Xiaobing et al. (2018) Clinically prevalent mutations in Mycobacterium tuberculosis alter propionate metabolism and mediate multidrug tolerance. Nat Microbiol 3:1032-1042|
|Linger, Yvonne; Knickerbocker, Christopher; Sipes, David et al. (2018) Genotyping Multidrug-Resistant Mycobacterium tuberculosis from Primary Sputum and Decontaminated Sediment with an Integrated Microfluidic Amplification Microarray Test. J Clin Microbiol 56:|
|Sakatos, Alexandra; Babunovic, Gregory H; Chase, Michael R et al. (2018) Posttranslational modification of a histone-like protein regulates phenotypic resistance to isoniazid in mycobacteria. Sci Adv 4:eaao1478|
|Thakore, Nitu; Norville, Ryan; Franke, Molly et al. (2018) Automated TruTip nucleic acid extraction and purification from raw sputum. PLoS One 13:e0199869|
|Thakore, Nitu; Garber, Steve; Bueno, Arial et al. (2018) A bench-top automated workstation for nucleic acid isolation from clinical sample types. J Microbiol Methods 148:174-180|
|Gong, Lingyan; Ouyang, Wei; Li, Zirui et al. (2017) Force fields of charged particles in micro-nanofluidic preconcentration systems. AIP Adv 7:125020|
|Yadon, Adam N; Maharaj, Kashmeel; Adamson, John H et al. (2017) A comprehensive characterization of PncA polymorphisms that confer resistance to pyrazinamide. Nat Commun 8:588|
|Calderón, R I; Velásquez, G E; Becerra, M C et al. (2017) Prevalence of pyrazinamide resistance and Wayne assay performance analysis in a tuberculosis cohort in Lima, Peru. Int J Tuberc Lung Dis 21:894-901|
|Rock, Jeremy M; Hopkins, Forrest F; Chavez, Alejandro et al. (2017) Programmable transcriptional repression in mycobacteria using an orthogonal CRISPR interference platform. Nat Microbiol 2:16274|
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