. The Data Management, Analysis and Resource Dissemination Core will be responsible for sample tracking, laboratory data management, data storage, and analysis required for the successful completion of this NIAID U19 application: Genomic Centers for Infectious Disease, RFA-AI-18-004. The research conducted in this U19 will use a combination of sequencing-based approaches including whole genome sequencing of cultured isolates, metagenomics, and transcriptomics to examine pathogenic microorganisms. Our expectation is that by understanding the interactions between commensals, pathogens, co-pathogens, and the host, this effort will lead to identification of novel therapeutics and interventions that improve disease outcomes. This research will result in a great volume of complex data sets. Our Data Core will provide state of the art genome assembly, annotation, and analysis tools to characterize viruses, bacteria, fungi, and parasites as well as their vectors and hosts. Additional comprehensive taxonomic, phylogenetic and functional profiling of metagenomics and metatranscriptomic data analyses methodologies will also be provided. We will work closely with the Technology Core to ensure the robust development of new techniques for the processing and analysis of new datatypes from novel sequencing technologies. We will also ensure that all data and analyses will be made available to the scientific community. We will deposit all of our data into public repositories (and NIAID Bioinformatics Resource Centers) along with the appropriate clinical metadata associated with each study.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI110820-07
Application #
9901441
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2020-04-01
Budget End
2021-03-31
Support Year
7
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of Maryland Baltimore
Department
Type
DUNS #
188435911
City
Baltimore
State
MD
Country
United States
Zip Code
21201
Robertson, Colin D; Hazen, Tracy H; Kaper, James B et al. (2018) Phosphotyrosine-Mediated Regulation of Enterohemorrhagic Escherichia coli Virulence. MBio 9:
Ndungo, Esther; Randall, Arlo; Hazen, Tracy H et al. (2018) A Novel Shigella Proteome Microarray Discriminates Targets of Human Antibody Reactivity following Oral Vaccination and Experimental Challenge. mSphere 3:
Hazen, Tracy H; Mettus, Roberta; McElheny, Christi L et al. (2018) Diversity among blaKPC-containing plasmids in Escherichia coli and other bacterial species isolated from the same patients. Sci Rep 8:10291
Chung, Matthew; Teigen, Laura; Liu, Hong et al. (2018) Targeted enrichment outperforms other enrichment techniques and enables more multi-species RNA-Seq analyses. Sci Rep 8:13377
Watkins, Tonya N; Gebremariam, Teclegiorgis; Swidergall, Marc et al. (2018) Inhibition of EGFR Signaling Protects from Mucormycosis. MBio 9:
Andrianaki, Angeliki M; Kyrmizi, Irene; Thanopoulou, Kalliopi et al. (2018) Iron restriction inside macrophages regulates pulmonary host defense against Rhizopus species. Nat Commun 9:3333
Hazen, Tracy H; Mettus, Roberta T; McElheny, Christi L et al. (2018) Draft Genome Sequences of blaKPC-Containing Enterobacter aerogenes, Citrobacter freundii, and Citrobacter koseri Strains. Genome Announc 6:
Broxton, Chynna N; He, Bixi; Bruno, Vincent M et al. (2018) A role for Candida albicans superoxide dismutase enzymes in glucose signaling. Biochem Biophys Res Commun 495:814-820
Higginson, Ellen E; Ramachandran, Girish; Hazen, Tracy H et al. (2018) Improving Our Understanding of Salmonella enterica Serovar Paratyphi B through the Engineering and Testing of a Live Attenuated Vaccine Strain. mSphere 3:
Richter, Taylor K S; Hazen, Tracy H; Lam, Diana et al. (2018) Temporal Variability of Escherichia coli Diversity in the Gastrointestinal Tracts of Tanzanian Children with and without Exposure to Antibiotics. mSphere 3:

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