The broad objectives of the Administrative Core (Core A) of the Atlantic Coast (AC) STI CRC are to provide the infrastructure needed to help the Center meet its long-term goal of increased understanding and improved control measures for chlamydia and gonorrhea infections. Dr. Ann Jerse will be the Core Leader and a Core Manager will assist her in the running of the core. The activities of Core A are organized around the following five specific aims and a management plan has been developed to address each aim.
Aim 1 is to foster interactive and synergistic interactions between Center PIs, co-PIs and Core Leaders to maximize research accomplishments and increase the types of significant breakthroughs that occur when experts in different fields work together. Mechanisms to accomplish this goal include monthly teleconferences for Center investigators and annual AC STI CRC meetings where Center PIs, coPIs and Core Leaders present their progress. An outside scientific advisory board (SAB) composed of researchers with diverse experience in STIs will attend two of the AC STI CRC meetings and provide critiques on the progress of individual Research Projects, the Research Cores, and the overall Center.
Aim 2 is to provide funds, mentorship, and networking opportunities to talented new investigators working in STI research through the Developmental Research Project (DRP) program. Core A will solicit calls for applications and organize the review panel and review process by which awardees will be selected. Core A will also play a role in developing a training plan for the awardee and will provide DRP awardees with the opportunty to attend and present at an annual NIAID programmatic STI CRC meeting.
Aim 3 is to actively facilitate good communications between the Henry Jackson Foundation, who will administer the awards and subawards of the Center, and administrative personnel at the different institutions within the Center. In this way, the accounting responsibilities of the center can be better discharged in an efficient and straightforward manner. Core A will provide administrative oversight with respect to maintaining all assurances for animal and human use.
Aim 4 is to regularly communicate with NIH/NIAID program staff so that our progress is transparent and we are aware of changes in programmatic focus. To promote these interactions, NIAID program staff will be invited to the annual internal AC STI CRC meetings.
Aim 5 is to broaden networks within the STI research community by actively seeking and identifying potential collaborations between Center researchers and investigators at other Centers. Besides helping to identify such collaborations, Core A will consult with NIAID program staff for information on expertises or technologies held by other Centers that might help PIs within our center.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
1U19AI113170-01
Application #
8769564
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
1
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Henry M. Jackson Fdn for the Adv Mil/Med
Department
Type
DUNS #
City
Bethesda
State
MD
Country
United States
Zip Code
20817
Zheng, Xiaojing; O'Connell, Catherine M; Zhong, Wujuan et al. (2018) Gene Expression Signatures Can Aid Diagnosis of Sexually Transmitted Infection-Induced Endometritis in Women. Front Cell Infect Microbiol 8:307
Kahler, Charlene M; Nawrocki, K L; Anandan, A et al. (2018) Structure-Function Relationships of the Neisserial EptA Enzyme Responsible for Phosphoethanolamine Decoration of Lipid A: Rationale for Drug Targeting. Front Microbiol 9:1922
Zhu, Weiyan; Tomberg, Joshua; Knilans, Kayla J et al. (2018) Properly folded and functional PorB from Neisseria gonorrhoeae inhibits dendritic cell stimulation of CD4+ T cell proliferation. J Biol Chem 293:11218-11229
Zheng, Xiaojing; O'Connell, Catherine M; Zhong, Wujuan et al. (2018) Discovery of Blood Transcriptional Endotypes in Women with Pelvic Inflammatory Disease. J Immunol 200:2941-2956
Rouquette-Loughlin, Corinne E; Dhulipala, Vijaya; Reimche, Jennifer L et al. (2018) cis- and trans-Acting Factors Influence Expression of the norM-Encoded Efflux Pump of Neisseria gonorrhoeae and Levels of Gonococcal Susceptibility to Substrate Antimicrobials. Antimicrob Agents Chemother 62:
Vincent, Leah R; Kerr, Samuel R; Tan, Yang et al. (2018) In Vivo-Selected Compensatory Mutations Restore the Fitness Cost of Mosaic penA Alleles That Confer Ceftriaxone Resistance in Neisseria gonorrhoeae. MBio 9:
Rouquette-Loughlin, Corinne E; Zalucki, Yaramah M; Dhulipala, Vijaya L et al. (2017) Control of gdhR Expression in Neisseria gonorrhoeae via Autoregulation and a Master Repressor (MtrR) of a Drug Efflux Pump Operon. MBio 8:
Rice, Peter A; Shafer, William M; Ram, Sanjay et al. (2017) Neisseria gonorrhoeae: Drug Resistance, Mouse Models, and Vaccine Development. Annu Rev Microbiol 71:665-686
Gangaiah, Dharanesh; Raterman, Erica L; Wu, Hong et al. (2017) Both MisR (CpxR) and MisS (CpxA) Are Required for Neisseria gonorrhoeae Infection in a Murine Model of Lower Genital Tract Infection. Infect Immun 85:
Taylor, Brandie D; Zheng, Xiaojing; Darville, Toni et al. (2017) Whole-Exome Sequencing to Identify Novel Biological Pathways Associated With Infertility After Pelvic Inflammatory Disease. Sex Transm Dis 44:35-41

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