Our Center seeks to usehigh-throughputpro?lingtechnologiestodeveloppredictivemodelsofLassafever and Ebola virusdiseaseatasystemsbiologylevel.Thesuccessofthismissionisdependentontheunique cohortsandinnovativepro?lingmethods,thecombinationofwhichwillresultinauniqueandpowerfuldata set.Inthiscontext,theoverallmissionoftheDataManagementandBioinformaticsCore(DMBC)istoensure that the Center utilizes best practices for data provenance, analysis, management, and dissemination throughoutthedatalifecycle.Toaccomplishthismission,wewillpromotetherobustcollectionandanalysis oftheprimarydata,developaframeworkforreproduciblework?owsthatcanbeusedacrosstheCenter,and maximize dissemination and reuse of Center-generated data and tools. OurmissionwillbeaccomplishedthroughthecompletionofthreeSpeci?cAims.
Aim1 focusesonaccurately capturing clinical and laboratory data, and then reproducibly processing them using robustwork?owtools.
This aim describesakey,foundationalfunctionthatiscriticalforthesuccessoftheCenter.
Aim2 focuseson dissemination of Center-generated resources according to FAIR principles - Findable, Accessible, Interoperable,andReusable.ThisworkwillensurethattheimpactofourCenterextendsbeyondourteam?s stated analysis plan, and it leverages our extensive work building tools for e?ective data and software dissemination.
Aim 3 focuses on directly engagingthecommunityincollaborationswithavarietyofgroups with complementary skills and assets. This work leverages the principlethatcollaborativeplatformsenable discoveries that would not be possible through individual investigations. Overall,webelievethatthisplanfortheDMBCo?ersabroadandsolidfoundationonwhichourCenter?sdata generation, data modeling, and biological discovery activities can build.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI135995-03
Application #
9851803
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2020-02-01
Budget End
2021-01-31
Support Year
3
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
781613492
City
La Jolla
State
CA
Country
United States
Zip Code
92037
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