Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19CA113297-02
Application #
7546138
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
Budget Start
2006-05-01
Budget End
2007-04-30
Support Year
2
Fiscal Year
2006
Total Cost
$244,054
Indirect Cost
Name
University of Wisconsin Madison
Department
Type
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Kim, Soyoung; Alexander, Caroline M (2014) Tumorsphere assay provides more accurate prediction of in vivo responses to chemotherapeutics. Biotechnol Lett 36:481-8
Lohman, Jeremy R; Huang, Sheng-Xiong; Horsman, Geoffrey P et al. (2013) Cloning and sequencing of the kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC 53650 revealing new insights into biosynthesis of the enediyne family of antitumor antibiotics. Mol Biosyst 9:478-91
Yang, Dong; Li, Wenli; Huang, Sheng-Xiong et al. (2012) Functional characterization of ttnI completing the tailoring steps for tautomycetin biosynthesis in Streptomyces griseochromogenes. Org Lett 14:1302-5
Kim, Soyoung; Roopra, Avtar; Alexander, Caroline M (2012) A phenotypic mouse model of basaloid breast tumors. PLoS One 7:e30979
Lin, Shuangjun; Huang, Tingting; Horsman, Geoff P et al. (2012) Specificity of the ester bond forming condensation enzyme SgcC5 in C-1027 biosynthesis. Org Lett 14:2300-3
Huang, Sheng-Xiong; Yu, Zhiguo; Robert, Francis et al. (2011) Cycloheximide and congeners as inhibitors of eukaryotic protein synthesis from endophytic actinomycetes Streptomyces sps. YIM56132 and YIM56141. J Antibiot (Tokyo) 64:163-6
Liu, Sijiu; Yu, Zhihong; Yu, Xiao et al. (2011) SHP2 is a target of the immunosuppressant tautomycetin. Chem Biol 18:101-10
Chen, Yihua; Yin, Min; Horsman, Geoff P et al. (2011) Improvement of the enediyne antitumor antibiotic C-1027 production by manipulating its biosynthetic pathway regulation in Streptomyces globisporus. J Nat Prod 74:420-4
Yang, Dong; Zhu, Xiangcheng; Wu, Xueyun et al. (2011) Titer improvement of iso-migrastatin in selected heterologous Streptomyces hosts and related analysis of mRNA expression by quantitative RT-PCR. Appl Microbiol Biotechnol 89:1709-19
Yu, Zhiguo; Zhao, Li-Xing; Jiang, Cheng-Lin et al. (2011) Bafilomycins produced by an endophytic actinomycete Streptomyces sp. YIM56209. J Antibiot (Tokyo) 64:159-62

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