The objectives of Project I are to create B-arrestin-biased dopamine D2R agonist clinical candidates for the treatment of schizophrenia and related disorders, and to create extremely G(1)-biased D2R agonists as chemical probes for elucidating the key signaling pathways essential for antipsychotic efficacy and side-effects. I have the expertise, leadership and motivation necessary to lead this medicinal chemistry project.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Program--Cooperative Agreements (U19)
Project #
2U19MH082441-06
Application #
8509176
Study Section
Special Emphasis Panel (ZMH1-ERB-C (03))
Project Start
2012-07-01
Project End
2017-04-30
Budget Start
2012-08-10
Budget End
2013-04-30
Support Year
6
Fiscal Year
2012
Total Cost
$380,000
Indirect Cost
$130,000
Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
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