As synchronous population events SPW-Rs are strongly implicated in the transmission of intra- hippocampally stored representations to extra-hippocampal targets, supporting the consolidation of memory at these targets. The primary hippocampal output originates from CA1 pyramidal cells (CA1PCs), and CA1PCs with specific cortical and subcortical extra-hippocampal targets are thought to be differentially distributed along the main hippocampal anatomical axes. In turn, recent studies demonstrated the presence of a large degree of morphological and functional heterogeneity within the CA1PC populations along these same hippocampal axes, suggesting the presence of target-specific functional subdivisions within the hippocampal network. However, the precise anatomical and functional organization, recruitment mechanisms and behavioral relevance of SPW-Rs along these extra-hippocampal target-specific subdivisions remain unknown. In Project 4, we will perform an extensive set of new correlational and pertubational experiments which will provide novel insights into CA1PC target-specific SPW-R organization and function.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19NS104590-04
Application #
9993615
Study Section
Special Emphasis Panel (ZNS1)
Project Start
Project End
Budget Start
2020-07-01
Budget End
2021-06-30
Support Year
4
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Stanford University
Department
Type
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94305
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