The Icahn School of Medicine at Mount Sinai will leverage our research expertise in environmental epidemiology, analytical chemistry and clinical practice to renew our Human Health Exposure Analysis Resource (HHEAR) Laboratory Network Hub (formerly known as ?CHEAR? in grant cycle 1). We will measure targeted chemical exposures across all life stages to help NIH funded researchers determine how the environment affects human health, development and risk of disease across the life span. In the last 3 years we have expanded our laboratory resources to include liquid handlers to automate sample prep/aliquoting and worked with data scientist to automate data processing to speed the pace of our jobs. In addition we doubled the number of mass spectrometers from 7 to 14 and hired additional faculty all in preparation for this renewal application. We will leverage our substantial institutional investments, including our new 30 million dollar Institute for Exposomics, to serve the HHEAR Lab network and its NIH researcher clients. Our targeted resource will analyze common exposure biomarkers (metals, pesticides, flame retardants, endocrine disrupting chemicals, tobacco metabolites, vitamins, nutritional status, minerals, and other organic compounds) using state-of-the-art analytical methodologies, while developing new biomarkers of chemical exposure based on the needs of our NIH clients. We will further build upon our work in CHEAR in which we created a suite of customizable panels that facilitate research in complex chemical mixtures. Our Developmental core will build upon its highly successful work in creating novel methods to measure current and past chemical exposures in novel biological matrices (e.g. teeth, hair, dried blood spots, placenta) and develop new assays that arise from hits from HHEAR's untargeted and environmental resources. This team already developed methods to objectively reconstruct past chemical exposures and identify susceptibility windows as they relate to human health in CHEAR. Our Administrative Core will coordinate planning and communication internally among all Hub components and externally with the HHEAR Coordinating Center, Data Center and the other HHEAR Network Hubs. Internally, the Administrative Core will streamline and prioritize HHEAR jobs, assess assay needs, promote and disseminate new assays as they are developed, harmonize protocols and QA/QC procedures and coordinate day to day operations. Our Hub will advise applicants on sample requirements, sample quality, results interpretation, sample collection, storage protocols and sample shipping specifications guiding them to exposures that fit the most up to date and innovative environmental health science. If necessary we will outreach to outside laboratories with analytic capabilities/expertise that do not reside in our Lab Hub. In conclusion, this proposal links highly experienced environmental health scientists with physicians, toxicologists, stress researchers, chemists, exposure scientists, epidemiologists, and computer scientists to build the infrastructure and capacity to objectively measure human environments.

Public Health Relevance

The Mount Sinai Human Health Exposure Analysis Resource (HHEAR) Laboratory Network Hub will advance public health in the United States by supporting state-of-the-art exposure science and biological response methods designed to discover the environmental causes of disease and disability in people of all ages.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Resource-Related Research Multi-Component Projects and Centers Cooperative Agreements (U2C)
Project #
2U2CES026561-02
Application #
9814353
Study Section
Special Emphasis Panel (ZES1)
Program Officer
Cui, Yuxia
Project Start
2015-09-30
Project End
2024-05-31
Budget Start
2019-09-05
Budget End
2020-05-31
Support Year
2
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Icahn School of Medicine at Mount Sinai
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
078861598
City
New York
State
NY
Country
United States
Zip Code
10029
Wright, Robert O; Teitelbaum, Susan; Thompson, Claudia et al. (2018) The child health exposure analysis resource as a vehicle to measure environment in the environmental influences on child health outcomes program. Curr Opin Pediatr 30:285-291
Sanders, Alison P; Saland, Jeffrey M; Wright, Robert O et al. (2018) Perinatal and childhood exposure to environmental chemicals and blood pressure in children: a review of literature 2007-2017. Pediatr Res 84:165-180
Curtin, Paul; Austin, Christine; Curtin, Austen et al. (2018) Dynamical features in fetal and postnatal zinc-copper metabolic cycles predict the emergence of autism spectrum disorder. Sci Adv 4:eaat1293
Smith, Tanya M; Austin, Christine; Hinde, Katie et al. (2017) Cyclical nursing patterns in wild orangutans. Sci Adv 3:e1601517
Wright, Robert O (2017) Environment, susceptibility windows, development, and child health. Curr Opin Pediatr 29:211-217
Andra, Syam S; Austin, Christine; Patel, Dhavalkumar et al. (2017) Trends in the application of high-resolution mass spectrometry for human biomonitoring: An analytical primer to studying the environmental chemical space of the human exposome. Environ Int 100:32-61
Wolff, Mary S; Buckley, Jessie P; Engel, Stephanie M et al. (2017) Emerging exposures of developmental toxicants. Curr Opin Pediatr 29:218-224
Evrard, Solene M; Lecce, Laura; Michelis, Katherine C et al. (2016) Endothelial to mesenchymal transition is common in atherosclerotic lesions and is associated with plaque instability. Nat Commun 7:11853
Kappil, Maya; Wright, Robert O; Sanders, Alison P (2016) Developmental Origins of Common Disease: Epigenetic Contributions to Obesity. Annu Rev Genomics Hum Genet 17:177-92
Andra, Syam S; Austin, Christine; Yang, Juan et al. (2016) Recent advances in simultaneous analysis of bisphenol A and its conjugates in human matrices: Exposure biomarker perspectives. Sci Total Environ 572:770-781

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