Genetically-engineered mice (transgenics, knockout and knock-ins) have become invaluable to almost all fields of medicine. Because of the importance of GEM to understanding human development and diseases and to creating improved drugs and therapeutics, tens of thousands of GEM have been created over the last decade. The MMRRC provides a unique repository service to the biomedical community for importing, storing and distributing a vast number of GEM as a resource for the biomedical community. Since the MMRRC Network began as a fledging repository in 1999/2000, it has evolved into a major resource for the biomedical community with capabilities and a combined inventory of mouse lines and embryonic stem (ES) cells that exceeds the capacity of other mouse repositories worldwide. The overall goal of this proposal is to continue and expand these functions and capabilities of the Mutant Mouse Regional Resource Center (MMRRC) at the University of Missouri to provide biomedical investigators with the mouse models and related reagents they require for their research.

Public Health Relevance

Genetically-engineered mice (transgenics, knockout and knock-ins) have become invaluable to almost all fields of medicine. Because of the importance of GEM to understanding human development and diseases and to creating improved drugs and therapeutics, tens of thousands of GEM have been created over the last decade. The MMRRC provides a unique repository service to the biomedical community for importing, storing and distributing a vast number of GEM as a resource for the biomedical community.

Agency
National Institute of Health (NIH)
Institute
Office of The Director, National Institutes of Health (OD)
Type
Animal (Mammalian and Nonmammalian) Model, and Animal and Biological Materials Resource Cooperative Agreements (U42)
Project #
5U42OD010918-15
Application #
8628203
Study Section
Special Emphasis Panel (ZRR1-CM-9 (01))
Program Officer
Mirochnitchenko, Oleg
Project Start
2000-05-01
Project End
2015-01-31
Budget Start
2014-02-01
Budget End
2015-01-31
Support Year
15
Fiscal Year
2014
Total Cost
$1,074,051
Indirect Cost
$834,795
Name
University of Missouri-Columbia
Department
Veterinary Sciences
Type
Schools of Veterinary Medicine
DUNS #
153890272
City
Columbia
State
MO
Country
United States
Zip Code
65211
Korte, Scott W; Franklin, Craig L; Dorfmeyer, Rebecca A et al. (2018) Effects of Fenbendazole-impregnated Feed and Topical Moxidectin during Quarantine on the Gut Microbiota of C57BL/6 Mice. J Am Assoc Lab Anim Sci 57:229-235
Bidot, Willie A; Ericsson, Aaron C; Franklin, Craig L (2018) Effects of water decontamination methods and bedding material on the gut microbiota. PLoS One 13:e0198305
Hart, Marcia L; Ericsson, Aaron C; Lloyd, K C Kent et al. (2018) Development of outbred CD1 mouse colonies with distinct standardized gut microbiota profiles for use in complex microbiota targeted studies. Sci Rep 8:10107
Montonye, Dan R; Ericsson, Aaron C; Busi, Susheel B et al. (2018) Acclimation and Institutionalization of the Mouse Microbiota Following Transportation. Front Microbiol 9:1085
Riesenberg, Amy N; Conley, Kevin W; Le, Tien T et al. (2018) Separate and coincident expression of Hes1 and Hes5 in the developing mouse eye. Dev Dyn 247:212-221
Niwa, Takahiko; Yamakoshi, Yasuo; Yamazaki, Hajime et al. (2018) The dynamics of TGF-? in dental pulp, odontoblasts and dentin. Sci Rep 8:4450
Ericsson, Aaron C; Gagliardi, Jonalyn; Bouhan, Delia et al. (2018) The influence of caging, bedding, and diet on the composition of the microbiota in different regions of the mouse gut. Sci Rep 8:4065
Khairallah, Marie-Therese; Astroski, Jacob; Custer, Sarah K et al. (2017) SMN deficiency negatively impacts red pulp macrophages and spleen development in mouse models of spinal muscular atrophy. Hum Mol Genet 26:932-941
Franklin, Craig L; Ericsson, Aaron C (2017) Microbiota and reproducibility of rodent models. Lab Anim (NY) 46:114-122
Hart, Marcia L; Ericsson, Aaron C; Franklin, Craig L (2017) Differing Complex Microbiota Alter Disease Severity of the IL-10-/- Mouse Model of Inflammatory Bowel Disease. Front Microbiol 8:792

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