This proposal seeks renewal of support for the infrastructure, personnel, and resources of the Mutant Mouse Resource and Research Center (MMRRC) at the University of California (UC) Davis (MMRRC-UCD). Since its inception 15 years ago, the MMRRC-UCD has been one of the primary mutant mouse archive and distribution repositories in the world. We are the largest of the 4 Centers in the MMRRC National Program, with an archive of over 30,392 mutant alleles representing ~93% of all live colonies, germplasm, and/or embryonic stem (ES) cells in the MMRRC system. The MMRRC-UCD has fulfilled nearly 4,754 orders from 3,214 investigators at 1,956 institutions in 23 countries. We have also been a leader in innovation and resource development for the system, introducing new products (e.g., targeted and gene trap ES cells) and initiating new services (e.g., blastocyst injection, ICSI, speed congenics) that have added scientific value to mouse models and enhanced utilization by the scientific research community of the MMRRC National Program. The MMRRC-UCD has leveraged its infrastructure and expertise to extend its service role by contracting with categorical NIH institutes (e.g., NINDS GENSAT project), biotechnology companies (Genentech and Lexicon), and several organizations (e.g., The Sanger Institute, Rockefeller University) to archive, distribute, custom breed, genotype, and phenotype 1000's of ES cell mutants and more than 1,500 BAC-transgenic, CRE, ENU-induced, and other mutant mouse collections. In addition, we have worked with the Centers and NIH program staff and developed and implemented advertising and marketing strategies, database management and informatics applications, website and online resources, customer and user services, operating procedures and policies, and shared governance of the national program. Thus, by archiving and delivering products and services effectively and efficiently, the MMRRC-UCD has established itself as a valuable scientific resource for the biomedical research community. Over the next 5 years, we shall focus our efforts on optimizing the quality of our resource, ensuring it relevance to individual users, and seeking maximum performance for the benefit of all whom we serve.

Public Health Relevance

The Mutant Mouse Resource and Research Center (MMRRC) National Consortium serves a primary role in ensuring that valuable mouse models of human disease, development, and behavioral abnormalities created in research laboratories are shared broadly among the biomedical scientific community. As one of 4 regional repositories and distribution centers in the Consortium, the MMRRC-UCD provides expertise, infrastructure, resources and services to preserve mouse strains in perpetuity, protect them from catastrophic loss, avoid genetic and phenotypic drift, and prevent pathogenic contamination and disease. By enabling availability and access of such valuable mouse models to the entire research community, the MMRRC-UCD fosters and promotes the discovery of new diagnostics, treatments, and prevention strategies against human diseases.

National Institute of Health (NIH)
Office of The Director, National Institutes of Health (OD)
Animal (Mammalian and Nonmammalian) Model, and Animal and Biological Materials Resource Cooperative Agreements (U42)
Project #
Application #
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Mirochnitchenko, Oleg
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California Davis
Schools of Medicine
United States
Zip Code
Shin, Sora; Pribiag, Horia; Lilascharoen, Varoth et al. (2018) Drd3 Signaling in the Lateral Septum Mediates Early Life Stress-Induced Social Dysfunction. Neuron 97:195-208.e6
Valero-Jiménez, Ana; Zúñiga, Joaquín; Cisneros, José et al. (2018) Transmembrane protease, serine 4 (TMPRSS4) is upregulated in IPF lungs and increases the fibrotic response in bleomycin-induced lung injury. PLoS One 13:e0192963
Jeong, Yeongseok; Huh, Namjung; Lee, Joonyeup et al. (2018) Role of the hippocampal CA1 region in incremental value learning. Sci Rep 8:9870
Hoerder-Suabedissen, Anna; Hayashi, Shuichi; Upton, Louise et al. (2018) Subset of Cortical Layer 6b Neurons Selectively Innervates Higher Order Thalamic Nuclei in Mice. Cereb Cortex 28:1882-1897
Lanjakornsiripan, Darin; Pior, Baek-Jun; Kawaguchi, Daichi et al. (2018) Layer-specific morphological and molecular differences in neocortical astrocytes and their dependence on neuronal layers. Nat Commun 9:1623
Tröster, Philip; Haseleu, Julia; Petersen, Jonas et al. (2018) The Absence of Sensory Axon Bifurcation Affects Nociception and Termination Fields of Afferents in the Spinal Cord. Front Mol Neurosci 11:19
Gelegen, Cigdem; Miracca, Giulia; Ran, Mingzi Z et al. (2018) Excitatory Pathways from the Lateral Habenula Enable Propofol-Induced Sedation. Curr Biol 28:580-587.e5
Ralvenius, William T; Neumann, Elena; Pagani, Martina et al. (2018) Itch suppression in mice and dogs by modulation of spinal ?2 and ?3GABAA receptors. Nat Commun 9:3230
McCullough, Kenneth M; Daskalakis, Nikolaos P; Gafford, Georgette et al. (2018) Cell-type-specific interrogation of CeA Drd2 neurons to identify targets for pharmacological modulation of fear extinction. Transl Psychiatry 8:164
Chen, Li; Chen, Ruju; Kemper, Sherri et al. (2018) Therapeutic effects of serum extracellular vesicles in liver fibrosis. J Extracell Vesicles 7:1461505

Showing the most recent 10 out of 97 publications