The Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR) Pilot/Demonstration Clinical Research Projects Program will support new ideas that have potential to create and/or change paradigms concerning eosinophilic esophagitis (EoE), eosinophilic gastritis (EG), and eosinophilic colitis (EC). We plan to support up to two Pilot/Demonstration Clinical Research Projects each year. The Pilot/Demonstration Clinical Research Projects will last up to two years and ideally take maximum advantage of new clinical research opportunities in investigating EoE, EG, and EC. The projects may be collaborative among investigators within one or more CEGIR sites or with investigators outside the CEGIR environment. We have already identified over ten exciting and cutting-edge projects that could become Pilot/Demonstration Clinical Research Projects, and a process for optimally identifying, selecting, and carrying out these projects is described.
The Pilot/Demonstration Clinical Research Projects Program will support research projects that encourage the development of new ideas concerning eosinophilic esophagitis, eosinophilic gastritis, and eosinophilic colitis. Projects will be selected by their likelihood to develop new models and ideas that will improve the way researchers, healthcare providers, and patients understand these diseases and to develop better treatments.
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| Rochman, Mark; Azouz, Nurit P; Rothenberg, Marc E (2018) Epithelial origin of eosinophilic esophagitis. J Allergy Clin Immunol 142:10-23 |
| Philpott, Hamish; Dellon, Evan (2018) Histologic improvement after 6 weeks of dietary elimination for eosinophilic esophagitis may be insufficient to determine efficacy. Asia Pac Allergy 8:e20 |
| Fahey, Lisa M; Chandramouleeswaran, Prasanna M; Guan, Shaobo et al. (2018) Food allergen triggers are increased in children with the TSLP risk allele and eosinophilic esophagitis. Clin Transl Gastroenterol 9:139 |
| Wechsler, Joshua B; Bolton, Scott M; Amsden, Katie et al. (2018) Eosinophilic Esophagitis Reference Score Accurately Identifies Disease Activity and Treatment Effects in Children. Clin Gastroenterol Hepatol 16:1056-1063 |
| Pesek, Robert D; Gupta, Sandeep K (2018) Emerging drugs for eosinophilic esophagitis. Expert Opin Emerg Drugs 23:173-183 |
| Spergel, Jonathan M; Aceves, Seema S; Kliewer, Kara et al. (2018) New developments in patients with eosinophilic gastrointestinal diseases presented at the CEGIR/TIGERS Symposium at the 2018 American Academy of Allergy, Asthma & Immunology Meeting. J Allergy Clin Immunol 142:48-53 |
| Mark, Jacob; Fernando, Shahan D; Masterson, Joanne C et al. (2018) Clinical Implications of Pediatric Colonic Eosinophilia. J Pediatr Gastroenterol Nutr 66:760-766 |
| Schwartz, Justin T; Morris, David W; Collins, Margaret H et al. (2018) Eosinophil progenitor levels correlate with tissue pathology in pediatric eosinophilic esophagitis. J Allergy Clin Immunol : |
| Ferguson, Anna E; Mukkada, Vince A; Fulkerson, Patricia C (2018) Pediatric Eosinophilic Esophagitis Endotypes: Are We Closer to Predicting Treatment Response? Clin Rev Allergy Immunol 55:43-55 |
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