The Human Measurement Core (HMC) will be led by Richard Bergman, PhD (physiology), DonnaSpruijt-Metz, PhD (behavior), and Hooman Allayee, PhD (genetics). This interdisciplinary team oinvestigators will provide a broad array of expertise and support across the center activities in thegeneral area of biological, behavioral and genetic measurements.
The Specific Aims of the HMC are thefollowing: 1) To provide efficient and high-quality trans-disciplinary measurement expertise to theprojects and pilot studies assessing: (a) Biological outcomes (body composition, fat distribution, anaobesity-related indices, oral glucose tolerance testing, insulin sensitivity and minimal modeling,measures of hormones, cytokines and lipids) and, (b) Behavioral outcomes (including dietary intake,physical activity assessment and accelerometry, and a variety of psychosocial measures) and (c).Genetic assays. 2) To consolidate lab measures to ensure high efficiency and to maintain consistencyamong studies for all measures. 3) To promote trans-disciplinary Research & Training in the variousmeasurement methods and expertise supplied by the HMC. 4) To provide analysis and interpretation ofmetabolic, endocrine, physical activity and diet parameters to the major projects and the pilot projects,and 5) To provide consultation to all projects and pilot studies on other available measures andresources. The HMC will be responsible for the choice and quality control of all measures across alprojects. We will assist in the choice of measures, analysis of data, and interpretation of findings in lightof current knowledge on insulin dynamics and other related fields. The HMC will assist in any necessaryadjustment of psychosocial measures to ensure that they are cultural and developmentally appropriateThe HMC will keep current with literature on all relevant measures and disseminate new information toproject leaders and other members of the center through seminars and frequent communications. Alprojects and pilot projects will use the HMC.
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