The Human Measurement Core (HMC) will be led by Richard Bergman, PhD (physiology), DonnaSpruijt-Metz, PhD (behavior), and Hooman Allayee, PhD (genetics). This interdisciplinary team oinvestigators will provide a broad array of expertise and support across the center activities in thegeneral area of biological, behavioral and genetic measurements.
The Specific Aims of the HMC are thefollowing: 1) To provide efficient and high-quality trans-disciplinary measurement expertise to theprojects and pilot studies assessing: (a) Biological outcomes (body composition, fat distribution, anaobesity-related indices, oral glucose tolerance testing, insulin sensitivity and minimal modeling,measures of hormones, cytokines and lipids) and, (b) Behavioral outcomes (including dietary intake,physical activity assessment and accelerometry, and a variety of psychosocial measures) and (c).Genetic assays. 2) To consolidate lab measures to ensure high efficiency and to maintain consistencyamong studies for all measures. 3) To promote trans-disciplinary Research & Training in the variousmeasurement methods and expertise supplied by the HMC. 4) To provide analysis and interpretation ofmetabolic, endocrine, physical activity and diet parameters to the major projects and the pilot projects,and 5) To provide consultation to all projects and pilot studies on other available measures andresources. The HMC will be responsible for the choice and quality control of all measures across alprojects. We will assist in the choice of measures, analysis of data, and interpretation of findings in lightof current knowledge on insulin dynamics and other related fields. The HMC will assist in any necessaryadjustment of psychosocial measures to ensure that they are cultural and developmentally appropriateThe HMC will keep current with literature on all relevant measures and disseminate new information toproject leaders and other members of the center through seminars and frequent communications. Alprojects and pilot projects will use the HMC.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA116848-03
Application #
7550596
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
Budget Start
2007-09-01
Budget End
2008-08-31
Support Year
3
Fiscal Year
2007
Total Cost
$340,277
Indirect Cost
Name
University of Southern California
Department
Type
DUNS #
072933393
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
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Duggan, Catherine; Stanczyk, Frank; Campbell, Kristin et al. (2016) Associations of sex steroid hormones with mortality in women with breast cancer. Breast Cancer Res Treat 155:559-67
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Kelly, Louise A; Loza, Armando; Lin, Xiao et al. (2015) The effect of a home-based strength training program on type 2 diabetes risk in obese Latino boys. J Pediatr Endocrinol Metab 28:315-22
Cook, Lauren T; O'Reilly, Gillian A; Goran, Michael I et al. (2014) Vegetable consumption is linked to decreased visceral and liver fat and improved insulin resistance in overweight Latino youth. J Acad Nutr Diet 114:1776-83
Duggan, Catherine; Risques, Rosana; Alfano, Catherine et al. (2014) Change in peripheral blood leukocyte telomere length and mortality in breast cancer survivors. J Natl Cancer Inst 106:dju035

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