Abstract

The purpose of the Bioinformatics and Biostatistics Resource (Core 4) is to support the data and knowledge management, statistical analysis and bioinformatics analysis needs of our proposed Center for Cancer Nanotechnology Excellence focused on Therapy Response (CCNE-TR) program. Our CCNE-TR proposal consists of 7 research projects and 4 cores that will work in concert to advance the discovery of life-saving molecularly targeted cancer therapies by developing and validating ex vivo diagnostics through tissue/serum-based proteomics nanosensors and in vivo diagnostics though nanoparticles for molecular imaging. Core 4 has three main goals in support of the overall CCNE-TR mission.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA119367-05
Application #
8073613
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
2013-04-30
Budget Start
2010-05-01
Budget End
2011-04-30
Support Year
5
Fiscal Year
2010
Total Cost
$255,468
Indirect Cost

  Institution

Name
Stanford University
Department
Type
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94305

  Publications

Shah, Preyas N; Lin, Tiras Y; Aanei, Ioana L et al. (2018) Extravasation of Brownian Spheroidal Nanoparticles through Vascular Pores. Biophys J 115:1103-1115
Kani, Kian; Garri, Carolina; Tiemann, Katrin et al. (2017) JUN-Mediated Downregulation of EGFR Signaling Is Associated with Resistance to Gefitinib in EGFR-mutant NSCLC Cell Lines. Mol Cancer Ther 16:1645-1657
Antaris, Alexander L; Chen, Hao; Diao, Shuo et al. (2017) A high quantum yield molecule-protein complex fluorophore for near-infrared II imaging. Nat Commun 8:15269
Smith, Bryan Ronain; Gambhir, Sanjiv Sam (2017) Nanomaterials for In Vivo Imaging. Chem Rev 117:901-986
Shou, Kangquan; Qu, Chunrong; Sun, Yao et al. (2017) Multifunctional biomedical imaging in physiological and pathological conditions using a NIR-II probe. Adv Funct Mater 27:
Feng, Yi; Zhu, Shoujun; Antaris, Alexander L et al. (2017) Live imaging of follicle stimulating hormone receptors in gonads and bones using near infrared II fluorophore. Chem Sci 8:3703-3711
Willmann, Jürgen K; Bonomo, Lorenzo; Carla Testa, Antonia et al. (2017) Ultrasound Molecular Imaging With BR55 in Patients With Breast and Ovarian Lesions: First-in-Human Results. J Clin Oncol 35:2133-2140
Antaris, Alexander L; Chen, Hao; Cheng, Kai et al. (2016) A small-molecule dye for NIR-II imaging. Nat Mater 15:235-42
Pu, Kanyi; Chattopadhyay, Niladri; Rao, Jianghong (2016) Recent advances of semiconducting polymer nanoparticles in in vivo molecular imaging. J Control Release 240:312-322
Zhang, Ruiping; Cheng, Kai; Antaris, Alexander L et al. (2016) Hybrid anisotropic nanostructures for dual-modal cancer imaging and image-guided chemo-thermo therapies. Biomaterials 103:265-277

Showing the most recent 10 out of 228 publications