The primary project will focus upon translation of imaging agents and devices developed at The Baylor College of Medicine (BCM) and translated in Phase I studies at The Michael E. DeBakey Veterans Administration Medical Center (MEDVAMC) as well as at Ben Taub General Hospital (BTGH). Dual labeled imaging agents for nuclear and fluorescence imaging will be produced under the BCM and LI-COR expertise in the Chemistry Core;imaged with near-infrared (NIR) fluorescence imaging and tomography devices built and algorithms written in the Instrumentation and Tomography Task Specific Projects;and approved following combinational FDA applications developed with safety and toxicity data generated in the Preclinical Testing Core. Initially we will translate two established agents which target (i) cancer cells within the lymphatic space and (ii) the reorganization of the stromal lymph node compartment as a hallmark of tumor malignancy in both breast cancer and melanoma patients. The results from Task Specific Projects that successfully validate additional candidate imaging agents will then be fed into the infrastructure of the primary project to conduct Phase 1 and Phase I/I I studies demonstrating nodal staging in Nuclear Medicine, intraoperative guidance for lymph node removal, and accurate molecular pathology. Provisions for including other consortia members are """"""""build into"""""""" the infrastructure of the network for nodal staging of cancer. This Network for Translational Research builds upon over a decade of development of (i) NIR conjugates for cancer targeting, (ii)novel instrumentation for time-dependent measurement of fluorescence in deep tissues, and (iii) innovative algorithms which enable non-contact imaging and integration with nuclear imaging modalities.
This Network for Translation Research will focus upon demonstrating dual-labeled imaging agents for nuclear and near-infrared molecular imaging for diagnostic nodal staging of cancer. If successful, diagnostic imaging could complement, guide, or even eliminate surgical resection of lymph nodes for staging purposes.
|Rasmussen, John C; Zvavanjanja, Rodrick C; Aldrich, Melissa B et al. (2017) Near-infrared fluorescence lymphatic imaging of Klippel-Trénaunay syndrome. J Vasc Surg Venous Lymphat Disord 5:533-537|
|Rasmussen, John C; Tan, I-Chih; Naqvi, Syed et al. (2017) Longitudinal monitoring of the head and neck lymphatics in response to surgery and radiation. Head Neck 39:1177-1188|
|Aldrich, Melissa B; Gross, Deborah; Morrow, John Rodney et al. (2017) Effect of pneumatic compression therapy on lymph movement in lymphedema-affected extremities, as assessed by near-infrared fluorescence lymphatic imaging. J Innov Opt Health Sci 10:|
|O'Donnell Jr, Thomas F; Rasmussen, John C; Sevick-Muraca, Eva M (2017) New diagnostic modalities in the evaluation of lymphedema. J Vasc Surg Venous Lymphat Disord 5:261-273|
|Greives, Matthew R; Aldrich, Melissa B; Sevick-Muraca, Eva M et al. (2017) Near-Infrared Fluorescence Lymphatic Imaging of a Toddler With Congenital Lymphedema. Pediatrics 139:|
|Rasmussen, John C; Aldrich, Melissa B; Tan, I-Chih et al. (2016) Lymphatic transport in patients with chronic venous insufficiency and venous leg ulcers following sequential pneumatic compression. J Vasc Surg Venous Lymphat Disord 4:9-17|
|Gonzalez-Garay, M L; Aldrich, M B; Rasmussen, J C et al. (2016) A novel mutation in CELSR1 is associated with hereditary lymphedema. Vasc Cell 8:1|
|Zhu, Banghe; Rasmussen, John C; Litorja, Maritoni et al. (2016) Determining the Performance of Fluorescence Molecular Imaging Devices Using Traceable Working Standards With SI Units of Radiance. IEEE Trans Med Imaging 35:802-11|
|Nixon, Mark; Stewart-Fitzgibbon, Randi; Fu, Jingqi et al. (2016) Skeletal muscle salt inducible kinase 1 promotes insulin resistance in obesity. Mol Metab 5:34-46|
|Wang, Xuejuan; Aldrich, Melissa B; Yang, Zhi et al. (2016) Influence of chelator and near-infrared dye labeling on biocharacteristics of dual-labeled trastuzumab-based imaging agents. Chin J Cancer Res 28:362-9|
Showing the most recent 10 out of 39 publications