The Center Organization and Infrastructure represents the operational backbone of this PS-OC. It will provide the overall communications network, management structure, administrative support, fiscal oversight, and linkage to all the projects and cores of the center. It will coordinate all project meetings, meetings of the internal and external committees which are part of the center and interface with other PS-OCs of the network. It will generate progress reports - both scientific and fiscal - for submission to NCI and will oversee the budget of each project and activities related to pilot and trans-network projects. The center Administrative team will maintain minutes of all Project meetings and will provide ad hoc support or problem-solving capability for Projects and others critical functions of the center. Collaborations between investigators and between projects will be encouraged and fostered through regularly scheduled meetings of the investigators and staff and by holding periodic scientific retreats. The administrative activities will be facilitated by centralizing bookkeeping functions, coordinating manuscript preparation, and planning travel and research group meetings. The management body of the center will consist of the Principal Investigator, Co-Principal Investigator, center administrative director, director of the education &training and outreach &dissemination activities of the center and the leaders of each of the 4 technical projects. This team will work closely the center administrative committee and the Principal Investigator and Co-Pl will represent the center on the PS-OC network steering committee. Decisions of what pilot projects are funded and what trans-network projects are realized will be made from a joint consensus of members of the center leadership &management and advisory committees.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Specialized Center--Cooperative Agreements (U54)
Project #
Application #
Study Section
Special Emphasis Panel (ZCA1-SRLB-9 (O1))
Program Officer
Nagahara, Larry
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Princeton University
Schools of Arts and Sciences
United States
Zip Code
Chalfin, Heather J; Kates, Max; van der Toom, Emma E et al. (2018) Characterization of Urothelial Cancer Circulating Tumor Cells with a Novel Selection-Free Method. Urology 115:82-86
de Groot, Amber E; Pienta, Kenneth J (2018) Epigenetic control of macrophage polarization: implications for targeting tumor-associated macrophages. Oncotarget 9:20908-20927
Wu, Amy; Liao, David; Kirilin, Vlamimir et al. (2018) Cancer dormancy and criticality from a game theory perspective. Cancer Converg 2:1
van der Toom, Emma E; Axelrod, Haley D; de la Rosette, Jean J et al. (2018) Prostate-specific markers to identify rare prostate cancer cells in liquid biopsies. Nat Rev Urol :
Valkenburg, Kenneth C; de Groot, Amber E; Pienta, Kenneth J (2018) Targeting the tumour stroma to improve cancer therapy. Nat Rev Clin Oncol 15:366-381
Chalfin, Heather J; Glavaris, Stephanie A; Malihi, Paymaneh D et al. (2018) Prostate Cancer Disseminated Tumor Cells are Rarely Detected in the Bone Marrow of Patients with Localized Disease Undergoing Radical Prostatectomy across Multiple Rare Cell Detection Platforms. J Urol 199:1494-1501
Maley, Carlo C; Aktipis, Athena; Graham, Trevor A et al. (2017) Classifying the evolutionary and ecological features of neoplasms. Nat Rev Cancer 17:605-619
Piotrowski-Daspit, Alexandra S; Simi, Allison K; Pang, Mei-Fong et al. (2017) A 3D Culture Model to Study How Fluid Pressure and Flow Affect the Behavior of Aggregates of Epithelial Cells. Methods Mol Biol 1501:245-257
Parsana, Princy; Amend, Sarah R; Hernandez, James et al. (2017) Identifying global expression patterns and key regulators in epithelial to mesenchymal transition through multi-study integration. BMC Cancer 17:447
Decker, A M; Cackowski, F C; Jung, Y et al. (2017) Biochemical Changes in the Niche Following Tumor Cell Invasion. J Cell Biochem 118:1956-1964

Showing the most recent 10 out of 105 publications