The theme of our BETRNet Research Center (RC) is to identify genetic determinants of Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) to enable genetic marker guided early detection, risk stratification, prevention and therapy. The BETRNet Patients Registry-Virtual Biorepository (PRVB) Core will interact with all RC investigators at our participating institutions to continue and improve the effective methods and designs that successfully enabled us to share human biospecimens and clinical data across institutions to efficiently achieve our project goals in our existing BETRNet and will enable success in our new projects. We communicate regularly with our RC investigators to make sure they have access to high quality, clinically annotated biospecimens for their research questions. In addition, the Core provides infrastructure and oversight for secure management of all biospecimen, clinical, demographic and molecular data from the BETRNet RC, working closely with our investigators and the BETRNet Administrative Core. The Core will ensure adherence to data sharing in adherence with the guidelines as outlined from the BETRNet Coordinating Center and the NCI BETRNet Program Office in order to provide biospecimens and data to other BETRNet RCs for research.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
2U54CA163060-06
Application #
9276258
Study Section
Special Emphasis Panel (ZCA1-RPRB-7 (J1))
Project Start
2011-09-26
Project End
2022-04-30
Budget Start
2017-04-01
Budget End
2018-03-31
Support Year
6
Fiscal Year
2017
Total Cost
$326,569
Indirect Cost
$97,684
Name
Case Western Reserve University
Department
Type
Domestic Higher Education
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
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Evans, Daniel R; Venkitachalam, Srividya; Revoredo, Leslie et al. (2018) Evidence for GALNT12 as a moderate penetrance gene for colorectal cancer. Hum Mutat 39:1092-1101
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Berger, Nathan A (2018) New light on the pancreatic cyst conundrum. Transl Cancer Res 7:S545-S548
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Moinova, Helen R; LaFramboise, Thomas; Lutterbaugh, James D et al. (2018) Identifying DNA methylation biomarkers for non-endoscopic detection of Barrett's esophagus. Sci Transl Med 10:
Stachler, Matthew D; Camarda, Nicholas D; Deitrick, Christopher et al. (2018) Detection of Mutations in Barrett's Esophagus Before Progression to High-Grade Dysplasia or Adenocarcinoma. Gastroenterology 155:156-167
Berger, Nathan A; Scacheri, Peter C (2018) Targeting Epigenetics to Prevent Obesity Promoted Cancers. Cancer Prev Res (Phila) 11:125-128
Venkitachalam, Srividya; Guda, Kishore (2017) Altered glycosyltransferases in colorectal cancer. Expert Rev Gastroenterol Hepatol 11:5-7

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