for Education & Outreach Education & Outreach Unit of PSOC@Penn The PSOC@Penn will support a wide variety of programs that aim to build a vibrant community of students, postdoctoral researchers, and scientists working on multidisciplinary approaches to understanding the physics of cancer with an aim of transforming the next generation of scientists, engineers, and clinicians. Penn graduate students and postdoctoral research associates participate in and are enriched by seminars, distinguished lectures, workshops, and short courses across the broad range of topics that cut across the research projects and cores. A biennial symposium serves as a focal point for cancer physics research by all researchers in the PSOC as well as a worldwide community of researchers. The Center sponsors a wide array of programs that include summer research experiences for undergraduate students along with meaningful early research experiences for high school students in the Philadelphia region. An annual series of teacher professional development programs ensures that local high school science teachers are provided with new content knowledge that will help enliven science curriculum making it more relevant to the lives of their students. To help jump-start this Unit under the Administrative Core and Center Lead PI, we will be advised by James McGonigle who is currently the Assistant Director in the Office of the Deputy Dean for Research, School of Engineering and Applied Science and whose biosketch illustrates extensive experience in the many aspects of the proposed programs. McGonigle has developed and managed education and outreach programs for NSF centers at the University of Pennsylvania, local museums and science centers, and a research laboratory. He has over twenty-five years experience recruiting undergraduate students for summer research experiences. He works closely with science teachers involved in summer research and assists them in incorporating new science content into local science curricula. Additionally, he teaches courses in science teaching methods at Penn's Graduate School of Education. McGonigle will help develop the initial structure of the education and outreach unit with input from the Center Advisory Committee, providing a plan for the early formative assessment, recruiting plans for undergraduate summer research programs, and outreach to area high schools for students and teachers. 1

National Institute of Health (NIH)
National Cancer Institute (NCI)
Specialized Center--Cooperative Agreements (U54)
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Special Emphasis Panel (ZCA1)
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University of Pennsylvania
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Lee, Calvin K; de Anda, Jaime; Baker, Amy E et al. (2018) Multigenerational memory and adaptive adhesion in early bacterial biofilm communities. Proc Natl Acad Sci U S A 115:4471-4476
Nair, Praful R; Alvey, Cory; Jin, Xiaoling et al. (2018) Filomicelles Deliver a Chemo-Differentiation Combination of Paclitaxel and Retinoic Acid That Durably Represses Carcinomas in Liver to Prolong Survival. Bioconjug Chem 29:914-927
Huang, Mo; Wang, Jingshu; Torre, Eduardo et al. (2018) SAVER: gene expression recovery for single-cell RNA sequencing. Nat Methods 15:539-542
Ban, Ehsan; Franklin, J Matthew; Nam, Sungmin et al. (2018) Mechanisms of Plastic Deformation in Collagen Networks Induced by Cellular Forces. Biophys J 114:450-461
Smith, Lucas R; Cho, Sangkyun; Discher, Dennis E (2018) Stem Cell Differentiation is Regulated by Extracellular Matrix Mechanics. Physiology (Bethesda) 33:16-25
Holle, Andrew W; Young, Jennifer L; Van Vliet, Krystyn J et al. (2018) Cell-Extracellular Matrix Mechanobiology: Forceful Tools and Emerging Needs for Basic and Translational Research. Nano Lett 18:1-8
Pfeifer, Charlotte R; Xia, Yuntao; Zhu, Kuangzheng et al. (2018) Constricted migration increases DNA damage and independently represses cell cycle. Mol Biol Cell 29:1948-1962
Xia, Yuntao; Ivanovska, Irena L; Zhu, Kuangzheng et al. (2018) Nuclear rupture at sites of high curvature compromises retention of DNA repair factors. J Cell Biol 217:3796-3808
Ramakrishnan, N; Bradley, Ryan P; Tourdot, Richard W et al. (2018) Biophysics of membrane curvature remodeling at molecular and mesoscopic lengthscales. J Phys Condens Matter 30:273001
Chen, Gang; Huang, Alexander C; Zhang, Wei et al. (2018) Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response. Nature 560:382-386

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