: This study seeks to identify the relationships between lead levels, intake of dietary fats and sugars, and dental caries experience in disadvantaged African-American children, and to identify how these variables in the parent/caregiver relate to the child?s oral health status. The purpose is to identify areas for successful intervention toward reducing the disparities between those with the poorest oral health and their better-off peers. The population to be studied is children ages 0-5, and their primary caregivers, in the poorest 39 census tracts in Detroit. To be eligible, children must be equal or lower than 250 percentof the federal poverty line. Children and caregivers will be followed-up for 4 years. There will be 3 cycles of data collection over that time, in years 2, 4, and 6, so that for each family there are 2 years between data collection points. For adequate statistical power, the intent is to have the final data collection cycle include 833 children. Sampling, conducted by the Methodological Core (MC) for the center, has the study beginning with 994 adult caregivers for interview and 1,089 children for examination (two age-eligible children per family can be accepted). Each caregiver will complete a food frequency questionnaire (FF9) at home for him/herself and for the child(ren). The completed FFQs will be brought to the clinical examination, at which time an interviewer will review the FFQs with the caregiver. At this same appointment, both caregiver and child(ren) will receive a dental examination, and an FFQ for the child will be completed by interview. The adult caregiver will be asked for a finger stick blood sample and a saliva aboutample (for lead assay); saliva samples will be sought from the children only at the exams in years 4 and 6. Participants will also be measured for height and weight at the first and later examinations. Data from these interviews, exams, and assays of the samples will be managed by the MC. For testing the hypotheses, the outcomes will be severe dental caries experience in the child, and exposures will be lead levels in child, and sugars and fats in the diets of child and caregiver. Other variables, such as the demographic information collected in other center studies and body mass index of the caregiver and child, will be included in the multivariate analyses to determine relative risk. Nested case-control studies, with several measures of caries as the outcomes, will also be conducted. The significance of this study will be that it will identify areas for intervention and produce a unique database from an African-American population. The child?s FFQ, to be developed for this study, will also be a valuable tool for other studies of child obesity and nutrition.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54DE014261-07
Application #
7473298
Study Section
Special Emphasis Panel (ZDE1)
Project Start
Project End
Budget Start
2007-08-01
Budget End
2008-07-31
Support Year
7
Fiscal Year
2007
Total Cost
$234,464
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Cheng, Jing; Cheng, Nancy F; Guo, Zijian et al. (2018) Mediation analysis for count and zero-inflated count data. Stat Methods Med Res 27:2756-2774
Lim, Sungwoo; Tellez, Marisol; Ismail, Amid I (2015) Dental caries development among African American children: results from a 4-year longitudinal study. Community Dent Oral Epidemiol 43:200-7
Heima, Masahiro; Milgrom, Peter (2015) Soda Consumption May Increase Risk of Dental Caries in Primary Teeth of Low-income African Americans. J Evid Based Dent Pract 15:200-1
Ismail, Amid I; Lim, Sungwoo; Tellez, Marisol (2015) Tooth Surface Level Caries Progression in the Primary Dentition among Preschool Children. Caries Res 49:442-8
Ismail, Amid I; Ondersma, Steven; Jedele, Jenefer M Willem et al. (2011) Evaluation of a brief tailored motivational intervention to prevent early childhood caries. Community Dent Oral Epidemiol 39:433-48
Lim, Sungwoo; Zoellner, Jamie M; Ajrouch, Kristine J et al. (2011) Overweight in childhood: the role of resilient parenting in African-American households. Am J Prev Med 40:329-33
Ismail, Amid I; Lim, Sungwoo; Sohn, Woosung (2011) A transition scoring system of caries increment with adjustment of reversals in longitudinal study: evaluation using primary tooth surface data. Community Dent Oral Epidemiol 39:61-8
Lee, Joyce M; Lim, Sungwoo; Zoellner, Jamie et al. (2010) Don't children grow out of their obesity? Weight transitions in early childhood. Clin Pediatr (Phila) 49:466-9
Ajrouch, Kristine J; Reisine, Susan; Lim, Sungwoo et al. (2010) Situational stressors among African-American women living in low-income urban areas: the role of social support. Women Health 50:159-75
Ajrouch, Kristine J; Reisine, Susan; Lim, Sungwoo et al. (2010) Perceived everyday discrimination and psychological distress: does social support matter? Ethn Health 15:417-34

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