? ? The function of the Administrative Core is to facilitate the overall organizational structure and administrative activities of the Center, interface with NIH/NIEHS staff, foster cooperation between Research Projects and Cores, encourage criticism and advice from the program's scientists, promote fiscal responsibility, and provide a flexible administrative structure to assure the continued excellence of the overall Center and its ability to meet milestones. The management of this U54 Center, provided by the Administrative Core, includes the Center Director, two Associate Directors with experience at managing interdisciplinary research programs in academia, industry and national laboratory; a lead statisticians experienced with transcriptomics and proteomics analysis; an Internal Steering Team made up of the Director, Associate Directors, additional Research Project and Core Leaders and two pre-eminent scientific advisors. Each Research Project and Core consists of staff with the expertise to accomplish all of the milestones set forth in this U54 application with the respective leaders responsible for the experimental design, planning and implementation in coordination with the Internal Steering Team. The Administrative Core will also provide statistical support for all Research Projects and Cores to assist in data analysis, sensor platform testing and validation. In addition, the Administrative Core will assume responsibility for (a) planning and coordination of research activities within the U54 Center, (b) promote cross-disciplinary and cross- organizational interactions, (c) coordinate statistical analyses of experimental data, (d) ensure effective liaison with the NIEHS and Exposure Biology research projects, (d) ensure effective fiscal and resources management and planning, (e) preparing programmatic center documents and reports, and provide travel and conferencing arrangements, and (g) facilitate technology transfer planning. ? ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54ES016015-02
Application #
7485222
Study Section
Special Emphasis Panel (ZES1-LKB-E (BR))
Program Officer
Shaughnessy, Daniel
Project Start
2007-08-15
Project End
2011-05-31
Budget Start
2008-06-10
Budget End
2009-05-31
Support Year
2
Fiscal Year
2008
Total Cost
$1,449,952
Indirect Cost
Name
Battelle Pacific Northwest Laboratories
Department
Type
DUNS #
032987476
City
Richland
State
WA
Country
United States
Zip Code
99352
Tanaka, Naoki; Takahashi, Shogo; Hu, Xiao et al. (2017) Growth arrest and DNA damage-inducible 45? protects against nonalcoholic steatohepatitis induced by methionine- and choline-deficient diet. Biochim Biophys Acta Mol Basis Dis 1863:3170-3182
Takahashi, Shogo; Fukami, Tatsuki; Masuo, Yusuke et al. (2016) Cyp2c70 is responsible for the species difference in bile acid metabolism between mice and humans. J Lipid Res 57:2130-2137
Song, Yang; Luo, Yanan; Zhu, Chengzhou et al. (2016) Recent advances in electrochemical biosensors based on graphene two-dimensional nanomaterials. Biosens Bioelectron 76:195-212
Webb-Robertson, Bobbie-Jo M; Wiberg, Holli K; Matzke, Melissa M et al. (2015) Review, evaluation, and discussion of the challenges of missing value imputation for mass spectrometry-based label-free global proteomics. J Proteome Res 14:1993-2001
Zhu, Chengzhou; Yang, Guohai; Li, He et al. (2015) Electrochemical sensors and biosensors based on nanomaterials and nanostructures. Anal Chem 87:230-49
Yang, Guohai; Zhu, Chengzhou; Du, Dan et al. (2015) Graphene-like two-dimensional layered nanomaterials: applications in biosensors and nanomedicine. Nanoscale 7:14217-31
Tanaka, Naoki; Takahashi, Shogo; Zhang, Yuan et al. (2015) Role of fibroblast growth factor 21 in the early stage of NASH induced by methionine- and choline-deficient diet. Biochim Biophys Acta 1852:1242-52
Tanaka, Naoki; Takahashi, Shogo; Fang, Zhong-Ze et al. (2014) Role of white adipose lipolysis in the development of NASH induced by methionine- and choline-deficient diet. Biochim Biophys Acta 1841:1596-607
Lee, Ai-Cheng; Du, Dan; Chen, Baowei et al. (2014) Electrochemical detection of leukemia oncogenes using enzyme-loaded carbon nanotube labels. Analyst 139:4223-30
Jin, Hongjun; Hallstrand, Teal S; Daly, Don S et al. (2014) A halotyrosine antibody that detects increased protein modifications in asthma patients. J Immunol Methods 403:17-25

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