Abstract

The Data Interpretation Core (DIG) performs computational genomics and proteomics analyses, conducts? statistical and pathway data analysis for gene expression microarray and high throughput mass spectrometric? proteomics, and develops tools for data computation and modeling. This Core serves as a tool for integrative? analysis of the comprehensive human genomic and proteomic data generated by the Program. Information? from this Core helps correlate gene expression and protein patterns with the immuno-inflammatory phenotypes? and clinical trajectories of injured patients.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54GM062119-07
Application #
7492886
Study Section
Special Emphasis Panel (ZGM1)
Project Start
Project End
Budget Start
2007-09-01
Budget End
2008-08-31
Support Year
7
Fiscal Year
2007
Total Cost
$739,102
Indirect Cost

  Institution

Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199

  Publications

Gale, Stephen C; Kocik, Jurek F; Creath, Robert et al. (2016) A comparison of initial lactate and initial base deficit as predictors of mortality after severe blunt trauma. J Surg Res 205:446-455
Agarwal, Shailesh; Loder, Shawn; Brownley, Cameron et al. (2016) Inhibition of Hif1? prevents both trauma-induced and genetic heterotopic ossification. Proc Natl Acad Sci U S A 113:E338-47
Lopez, Maria-Cecilia; Efron, Philip A; Ozrazgat-Baslanti, Tezcan et al. (2016) Sex-based differences in the genomic response, innate immunity, organ dysfunction, and clinical outcomes after severe blunt traumatic injury and hemorrhagic shock. J Trauma Acute Care Surg 81:478-85
Sood, Ravi F; Gibran, Nicole S; Arnoldo, Brett D et al. (2016) Early leukocyte gene expression associated with age, burn size, and inhalation injury in severely burned adults. J Trauma Acute Care Surg 80:250-7
Mathias, Brittany; Lipori, Gigi; Moldawer, Lyle L et al. (2016) Integrating ""big data"" into surgical practice. Surgery 159:371-4
Mason, Stephanie A; Nathens, Avery B; Finnerty, Celeste C et al. (2016) Hold the Pendulum: Rates of Acute Kidney Injury are Increased in Patients Who Receive Resuscitation Volumes Less than Predicted by the Parkland Equation. Ann Surg 264:1142-1147
Nacionales, Dina C; Szpila, Benjamin; Ungaro, Ricardo et al. (2015) A Detailed Characterization of the Dysfunctional Immunity and Abnormal Myelopoiesis Induced by Severe Shock and Trauma in the Aged. J Immunol 195:2396-407
Seok, Junhee; Xu, Weihong; Davis, Ronald W et al. (2015) RASA: Robust Alternative Splicing Analysis for Human Transcriptome Arrays. Sci Rep 5:11917
Tsurumi, Amy; Que, Yok-Ai; Yan, Shuangchun et al. (2015) Do standard burn mortality formulae work on a population of severely burned children and adults? Burns 41:935-45
Vanzant, Erin L; Ozrazgat-Baslanti, Tezcan; Liu, Huazhi et al. (2015) Clostridium difficile Infections after Blunt Trauma: A Different Patient Population? Surg Infect (Larchmt) 16:421-7

Showing the most recent 10 out of 199 publications