Abstract

Core B - Primate Core (Stefan Schlatt. Director) Plant, Tony M. Core B maintains rhesus and cynomolgus monkeys for investigators of the U54 Center that employ the macaque as an experimental paradigm for the study of human reproductive processes. Adult females are used by Dr. Zeleznik. Prepubertal and adult males are used by Drs. Plant and Schlatt. Additionally, tissues generated by these investigators are shared with, or provided to, Drs. Jens Ehmcke, Elizabeth McGee, Kyle Orwig, Nuria Pastor-Soler and William Walker. The Core supports a remote sampling/infusion facility for investigators requiring continual access to the venous and cerebroventricular circulations, and a semen analysis service for investigators studying spermatogenesis in the macaque. Also, the Core Director maintains a rhesus breeding program to supply a limited number of neonatal and infantile male rhesus monkey for U54 and U54 approved projects (Projects I, II and VI). When necessary, the Core maintains animals from which control serum pools are harvested for endocrine assays in the Assay Core.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54HD008610-35
Application #
8053362
Study Section
Special Emphasis Panel (ZHD1)
Project Start
Project End
2013-03-31
Budget Start
2010-04-01
Budget End
2013-03-31
Support Year
35
Fiscal Year
2010
Total Cost
$152,450
Indirect Cost

  Institution

Name
University of Pittsburgh
Department
Type
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213

  Publications

Kawwass, Jennifer F; Sanders, Kristen M; Loucks, Tammy L et al. (2017) Increased cerebrospinal fluid levels of GABA, testosterone and estradiol in women with polycystic ovary syndrome. Hum Reprod 32:1450-1456
Vargas Trujillo, Marcela; Kalil, Bruna; Ramaswamy, Suresh et al. (2017) Estradiol Upregulates Kisspeptin Expression in the Preoptic Area of both the Male and Female Rhesus Monkey (Macaca mulatta): Implications for the Hypothalamic Control of Ovulation in Highly Evolved Primates. Neuroendocrinology 105:77-89
Kalil, Bruna; Ramaswamy, Suresh; Plant, Tony M (2016) The Distribution of Substance P and Kisspeptin in the Mediobasal Hypothalamus of the Male Rhesus Monkey and a Comparison of Intravenous Administration of These Peptides to Release GnRH as Reflected by LH Secretion. Neuroendocrinology 103:711-23
Walker, William H; Easton, Evan; Moreci, Rebecca S et al. (2015) Restoration of spermatogenesis and male fertility using an androgen receptor transgene. PLoS One 10:e0120783
Lomniczi, Alejandro; Wright, Hollis; Castellano, Juan Manuel et al. (2015) Epigenetic regulation of puberty via Zinc finger protein-mediated transcriptional repression. Nat Commun 6:10195
Shahab, M; Trujillo, M Vargas; Plant, T M (2015) A Reevaluation of the Question: Is the Pubertal Resurgence in Pulsatile GnRH Release in the Male Rhesus Monkey (Macaca mulatta) Associated With a Gonad-Independent Augmentation of GH Secretion? Endocrinology 156:3717-24
Verhagen, I; Ramaswamy, S; Teerds, K J et al. (2014) Time course and role of luteinizing hormone and follicle-stimulating hormone in the expansion of the Leydig cell population at the time of puberty in the rhesus monkey (Macaca mulatta). Andrology 2:924-30
Ramaswamy, Suresh; Dwarki, Karthik; Ali, Barkat et al. (2013) The decline in pulsatile GnRH release, as reflected by circulating LH concentrations, during the infant-juvenile transition in the agonadal male rhesus monkey (Macaca mulatta) is associated with a reduction in kisspeptin content of KNDy neurons of the arc Endocrinology 154:1845-53
Terasawa, Ei; Guerriero, Kathryn A; Plant, Tony M (2013) Kisspeptin and puberty in mammals. Adv Exp Med Biol 784:253-73
Stephens, Sahar M; Pau, Francis K Y; Yalcinkaya, Tamer M et al. (2013) Assessing the pulsatility of luteinizing hormone in female vervet monkeys (Chlorocebus aethiops sabaeus). Comp Med 63:432-8

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