The primary objective of the UC Davis MIND Institute IDDRC Neurobehavioral Analysis Core (NAC) is to help investigators generate detailed phenotypic characterizations of individuals with Intellectual and Developmental Disabilities (IDD). Phenotypic characterization requires measures that are appropriate for a representative sample of individuals with IDD and are designed, executed, and analyzed with the most precision and fidelity possible. Existing standardized tests, rating scales, and checklists are often not adequate for such characterization and adaptations of such measures or the creation of new measures are required. Moreover, many measures are often applicable to only a very narrow segment of the IDD population of interest. The NAC will assist IDDRC investigators in ensuring that they have the measures needed to generate advanced biobehavioral characterizations that can stand alone, be used to assess environmental contributions to IDD, or provide the evidence base for the development and evaluation of targeted treatments for IDD. To achieve this objective, the NAC will draw on the interdisciplinary expertise and already developed measures of several MIND Institute and UC Davis faculty and staff to provide key services for investigators conducting neurobiological studies of cognition, emotion, language, and other aspects of brain and behavior in human research participants with neurodevelopmental disorders that create IDD.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
1U54HD079125-01
Application #
8659020
Study Section
Special Emphasis Panel (ZHD1-DSR-H (50))
Project Start
2013-09-24
Project End
2018-06-30
Budget Start
2013-09-24
Budget End
2014-06-30
Support Year
1
Fiscal Year
2013
Total Cost
$130,658
Indirect Cost
$45,815
Name
University of California Davis
Department
Type
DUNS #
047120084
City
Davis
State
CA
Country
United States
Zip Code
95618
Gulinello, Maria; Mitchell, Heather A; Chang, Qiang et al. (2018) Rigor and reproducibility in rodent behavioral research. Neurobiol Learn Mem :
Vogel Ciernia, Annie; Careaga, Milo; LaSalle, Janine M et al. (2018) Microglia from offspring of dams with allergic asthma exhibit epigenomic alterations in genes dysregulated in autism. Glia 66:505-521
Adhikari, Anna; Copping, Nycole A; Onaga, Beth et al. (2018) Cognitive deficits in the Snord116 deletion mouse model for Prader-Willi syndrome. Neurobiol Learn Mem :
Nelson, Sarah; McDuffie, Andrea; Banasik, Amy et al. (2018) Inferential language use by school-aged boys with fragile X syndrome: Effects of a parent-implemented spoken language intervention. J Commun Disord 72:64-76
Jones, Karen L; Van de Water, Judy (2018) Maternal autoantibody related autism: mechanisms and pathways. Mol Psychiatry :
Jones, Karen L; Pride, Michael C; Edmiston, Elizabeth et al. (2018) Autism-specific maternal autoantibodies produce behavioral abnormalities in an endogenous antigen-driven mouse model of autism. Mol Psychiatry :
Ligsay, Andrew; El-Deeb, Marwa; Salcedo-Arellano, Maria J et al. (2018) General Anesthetic Use in Fragile X Spectrum Disorders. J Neurosurg Anesthesiol :
Silverman, Jill L; Ellegood, Jacob (2018) Behavioral and neuroanatomical approaches in models of neurodevelopmental disorders: opportunities for translation. Curr Opin Neurol 31:126-133
Conners, Frances A; Tungate, Andrew S; Abbeduto, Leonard et al. (2018) Growth and Decline in Language and Phonological Memory Over Two Years Among Adolescents With Down Syndrome. Am J Intellect Dev Disabil 123:103-118
Shelton, Annie L; Wang, Jun Y; Fourie, Emily et al. (2018) Middle Cerebellar Peduncle Width-A Novel MRI Biomarker for FXTAS? Front Neurosci 12:379

Showing the most recent 10 out of 175 publications